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    Recent advances in the engineering of nanosized active pharmaceutical ingredients: Promises and challenges

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    Authors
    Kaialy, Waseem
    Al Shafiee, Maen
    Issue Date
    2015-12-08
    
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    Abstract
    The advances in the field of nanotechnology have revolutionized the field of delivery of poorly soluble active pharmaceutical ingredients (APIs). Nanosized formulations have been extensively investigated to achieve a rapid dissolution and therefore pharmacokinetic properties similar to those observed in solutions. The present review outlines the recent advances, promises and challenges of the engineering nanosized APIs. The principles, merits, demerits and applications of the current ‘bottom-up’ and ‘top-down’ technologies by which the state of the art nanosized APIs can be produced were described. Although the number of research reports on the nanoparticle engineering topic has been growing in the last decade, the challenge is to take numerous research outcomes and convert them into strategies for the development of marketable products.
    Citation
    Recent advances in the engineering of nanosized active pharmaceutical ingredients: Promises and challenges 2016, 228:71 Advances in Colloid and Interface Science
    Publisher
    Elsevier BV
    Journal
    Advances in Colloid and Interface Science
    URI
    http://hdl.handle.net/2436/601336
    DOI
    10.1016/j.cis.2015.11.010
    Additional Links
    http://linkinghub.elsevier.com/retrieve/pii/S0001868615002183
    Type
    Journal article
    Language
    en
    ISSN
    00018686
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.cis.2015.11.010
    Scopus Count
    Collections
    Research Institute in Healthcare Science

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