The use of freeze-dried mannitol to enhance the in vitro aerosolization behaviour of budesonide from the Aerolizer®
dc.contributor.author | Kaialy, Waseem | |
dc.contributor.author | Nokhodchi, Ali | |
dc.date.accessioned | 2016-03-11T09:34:18Z | en |
dc.date.available | 2016-03-11T09:34:18Z | en |
dc.date.issued | 2015-11-14 | en |
dc.identifier.citation | Kaialy, W. & Nokhodchi, A. (2016) The use of freeze-dried mannitol to enhance the in vitro aerosolization behaviour of budesonide from the Aerolizer®, Powder Technology, 288, pp. 291-302 | en |
dc.identifier.issn | 00325910 | |
dc.identifier.doi | 10.1016/j.powtec.2015.11.016 | |
dc.identifier.uri | http://hdl.handle.net/2436/601156 | |
dc.description | This is a metadata record only. The full text of the article is not available in this repository. | en |
dc.description.abstract | The efficiency of drug delivery from drug-carrier dry powder inhaler (DPI) systems is typically low. The purpose of this study was to examine the aerosolization performance of a hydrophobic drug, budesonide (BUD), from DPI formulations containing a promising carrier, freeze-dried mannitol (FDM), and to compare the results to those obtained previously with a hydrophilic drug, salbutamol sulphate (SS). The results showed that, in comparison to the formulation containing commercial BUD and commercial lactose, a total of 3.8-fold increase in the fine particle fraction (FPF) was obtained from the formulation containing FDM (FPF: 7.5% versus 29%) whereas a total of 4.6-fold increase in the FPF was obtained from the formulation containing FDM and leucine additive (FPF: 35%). Regression analysis showed DPI formulations containing carrier particles with a more elongated/less spherical shape, a higher content of fine particulates (< 5 μm) and a higher porosity to produce higher FPFs of BUD. FDM promoted the aerosolization of budesonide intended for pulmonary delivery. The addition of leucine (by 4.8%, w/w) has further improved the flow and the aerosolization properties of FDM. FDM produced higher aerodynamic diameters and smaller FPFs of BUD as compared to SS, attributable to BUD having a higher electrostatic charge density and a higher agglomeration tendency than SS. | |
dc.language.iso | en | |
dc.publisher | Elsevier B.V. | en |
dc.relation.url | http://linkinghub.elsevier.com/retrieve/pii/S0032591015301595 | |
dc.subject | Dry powder inhalers | en |
dc.subject | Inhalations | en |
dc.subject | Interactive mixtures | en |
dc.subject | Mannitol | en |
dc.subject | Physicochemical properties | en |
dc.title | The use of freeze-dried mannitol to enhance the in vitro aerosolization behaviour of budesonide from the Aerolizer® | en |
dc.type | Journal article | en |
dc.identifier.journal | Powder Technology | en |
html.description.abstract | The efficiency of drug delivery from drug-carrier dry powder inhaler (DPI) systems is typically low. The purpose of this study was to examine the aerosolization performance of a hydrophobic drug, budesonide (BUD), from DPI formulations containing a promising carrier, freeze-dried mannitol (FDM), and to compare the results to those obtained previously with a hydrophilic drug, salbutamol sulphate (SS). The results showed that, in comparison to the formulation containing commercial BUD and commercial lactose, a total of 3.8-fold increase in the fine particle fraction (FPF) was obtained from the formulation containing FDM (FPF: 7.5% versus 29%) whereas a total of 4.6-fold increase in the FPF was obtained from the formulation containing FDM and leucine additive (FPF: 35%). Regression analysis showed DPI formulations containing carrier particles with a more elongated/less spherical shape, a higher content of fine particulates (< 5 μm) and a higher porosity to produce higher FPFs of BUD. FDM promoted the aerosolization of budesonide intended for pulmonary delivery. The addition of leucine (by 4.8%, w/w) has further improved the flow and the aerosolization properties of FDM. FDM produced higher aerodynamic diameters and smaller FPFs of BUD as compared to SS, attributable to BUD having a higher electrostatic charge density and a higher agglomeration tendency than SS. | en |