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dc.contributor.authorKaialy, Waseem
dc.contributor.authorNokhodchi, Ali
dc.date.accessioned2015-08-27T14:51:07Zen
dc.date.available2015-08-27T14:51:07Zen
dc.date.issued2013-07
dc.identifier.citationEngineered mannitol ternary additives improve dispersion of lactose-salbutamol sulphate dry powder inhalations. 2013, 15 (3):728-43 AAPS J
dc.identifier.issn1550-7416
dc.identifier.pmid23591748
dc.identifier.doi10.1208/s12248-013-9476-4
dc.identifier.urihttp://hdl.handle.net/2436/576021
dc.description.abstractThe aim of this study was to evaluate the influence of novel engineered fine mannitol particles (4.7%, w/w) on the performance of lactose-salbutamol sulphate dry powder inhaler (DPI) formulations to obtain promising aerosolisation properties. The results showed that the more elongated the fine mannitol particles, the weaker the drug-carrier adhesion, the better the drug content homogeneity, the higher the amount of drug expected to be delivered to the lower airways and the higher the total DPI formulation desirability. Linear relationships were established showing that mannitol particles with a more elongated shape generated powders with broader size distributions and that were less uniform in shape. The weaker the drug-carrier adhesion, the higher the fine particle fraction of the drug is upon aerosolisation. It is believed that more elongated fine mannitol particles reduce the number of drug-carrier and drug-drug physical contact points and increase the ability of the drug particles to travel into the lower airways. Additionally, a lower drug-carrier contact area, lower drug-carrier press-on forces and easier drug-carrier detachment are suggested in the case of formulations containing more elongated fine mannitol particles. Ternary 'drug-coarse carrier-elongated fine ternary component' DPI formulations were more favourable than both 'drug-coarse carrier' and 'drug-elongated coarse carrier' binary formulations. This study provides a comprehensive approach for formulators to overcome the undesirable properties of dry powder inhalers, as both improved aerosolisation performance and reasonable flow characteristics were obtained using only a small amount of elongated engineered fine mannitol particles.
dc.language.isoen
dc.publisherSpringer
dc.subjectadded fines
dc.subjectadhesive mixtures
dc.subjectengineered fine mannitol
dc.subjectformulation performance
dc.subjectternary component
dc.subject.meshAlbuterol
dc.subject.meshChemical Engineering
dc.subject.meshChemistry, Pharmaceutical
dc.subject.meshDry Powder Inhalers
dc.subject.meshLactose
dc.subject.meshMannitol
dc.subject.meshParticle Size
dc.subject.meshSulfates
dc.subject.meshX-Ray Diffraction
dc.titleEngineered mannitol ternary additives improve dispersion of lactose-salbutamol sulphate dry powder inhalations.
dc.typeJournal article
dc.identifier.journalThe AAPS journal
html.description.abstractThe aim of this study was to evaluate the influence of novel engineered fine mannitol particles (4.7%, w/w) on the performance of lactose-salbutamol sulphate dry powder inhaler (DPI) formulations to obtain promising aerosolisation properties. The results showed that the more elongated the fine mannitol particles, the weaker the drug-carrier adhesion, the better the drug content homogeneity, the higher the amount of drug expected to be delivered to the lower airways and the higher the total DPI formulation desirability. Linear relationships were established showing that mannitol particles with a more elongated shape generated powders with broader size distributions and that were less uniform in shape. The weaker the drug-carrier adhesion, the higher the fine particle fraction of the drug is upon aerosolisation. It is believed that more elongated fine mannitol particles reduce the number of drug-carrier and drug-drug physical contact points and increase the ability of the drug particles to travel into the lower airways. Additionally, a lower drug-carrier contact area, lower drug-carrier press-on forces and easier drug-carrier detachment are suggested in the case of formulations containing more elongated fine mannitol particles. Ternary 'drug-coarse carrier-elongated fine ternary component' DPI formulations were more favourable than both 'drug-coarse carrier' and 'drug-elongated coarse carrier' binary formulations. This study provides a comprehensive approach for formulators to overcome the undesirable properties of dry powder inhalers, as both improved aerosolisation performance and reasonable flow characteristics were obtained using only a small amount of elongated engineered fine mannitol particles.


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