Engineered mannitol ternary additives improve dispersion of lactose-salbutamol sulphate dry powder inhalations.
AbstractThe aim of this study was to evaluate the influence of novel engineered fine mannitol particles (4.7%, w/w) on the performance of lactose-salbutamol sulphate dry powder inhaler (DPI) formulations to obtain promising aerosolisation properties. The results showed that the more elongated the fine mannitol particles, the weaker the drug-carrier adhesion, the better the drug content homogeneity, the higher the amount of drug expected to be delivered to the lower airways and the higher the total DPI formulation desirability. Linear relationships were established showing that mannitol particles with a more elongated shape generated powders with broader size distributions and that were less uniform in shape. The weaker the drug-carrier adhesion, the higher the fine particle fraction of the drug is upon aerosolisation. It is believed that more elongated fine mannitol particles reduce the number of drug-carrier and drug-drug physical contact points and increase the ability of the drug particles to travel into the lower airways. Additionally, a lower drug-carrier contact area, lower drug-carrier press-on forces and easier drug-carrier detachment are suggested in the case of formulations containing more elongated fine mannitol particles. Ternary 'drug-coarse carrier-elongated fine ternary component' DPI formulations were more favourable than both 'drug-coarse carrier' and 'drug-elongated coarse carrier' binary formulations. This study provides a comprehensive approach for formulators to overcome the undesirable properties of dry powder inhalers, as both improved aerosolisation performance and reasonable flow characteristics were obtained using only a small amount of elongated engineered fine mannitol particles.
CitationEngineered mannitol ternary additives improve dispersion of lactose-salbutamol sulphate dry powder inhalations. 2013, 15 (3):728-43 AAPS J
JournalThe AAPS journal
- Spray-Congealing and Wet-Sieving as Alternative Processes for Engineering of Inhalation Carrier Particles: Comparison of Surface Properties, Blending and In Vitro Performance.
- Authors: Pinto JT, Zellnitz S, Guidi T, Schiaretti F, Schroettner H, Paudel A
- Issue date: 2021 Jun
- The influence of physical properties and morphology of crystallised lactose on delivery of salbutamol sulphate from dry powder inhalers.
- Authors: Kaialy W, Martin GP, Larhrib H, Ticehurst MD, Kolosionek E, Nokhodchi A
- Issue date: 2012 Jan 1
- Dry powder inhalers: physicochemical and aerosolization properties of several size-fractions of a promising alterative carrier, freeze-dried mannitol.
- Authors: Kaialy W, Nokhodchi A
- Issue date: 2015 Feb 20
- Effect of carrier particle shape on dry powder inhaler performance.
- Authors: Kaialy W, Alhalaweh A, Velaga SP, Nokhodchi A
- Issue date: 2011 Dec 12
- Co-spraying of carriers (mannitol-lactose) as a method to improve aerosolization performance of salbutamol sulfate dry powder inhaler.
- Authors: Ferdynand MS, Nokhodchi A
- Issue date: 2020 Oct