• Admin Login
    View Item 
    •   Home
    • Research Institute in Healthcare Science
    • Research Institute in Healthcare Science
    • View Item
    •   Home
    • Research Institute in Healthcare Science
    • Research Institute in Healthcare Science
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of WIRECommunitiesTitleAuthorsIssue DateSubmit DateSubjectsTypesJournalDepartmentPublisherThis CollectionTitleAuthorsIssue DateSubmit DateSubjectsTypesJournalDepartmentPublisher

    Administrators

    Admin Login

    Local Links

    AboutThe University LibraryOpen Access Publications PolicyDeposit LicenceCOREWIRE Copyright and Reuse Information

    Statistics

    Display statistics

    Investigation of drug release from PEO tablet matrices in the presence of vitamin E as antioxidant.

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Authors
    Shojaee, Saeed
    Nokhodchi, Ali
    Cumming, Iain
    Alhalaweh, Amjad
    Kaialy, Waseem
    Issue Date
    2015-03-26
    
    Metadata
    Show full item record
    Abstract
    The objective of this study wasto investigate the influence of drug type on the release of drug from PEO matrix tablets accompanied with the impact of vitamin E succinate as antioxidant.The resulted showed that the presence of vitamin E promoted a stable release rate of soluble drug propranolol HClfrom aged PEO matrix tablets, which was similar to fresh sample, regardless of molecular weight (MW) of PEO. However, the influence of the presence of vitamin E on the release rate of partially soluble drug, theophylline, was dependent on the MW of PEO; i.e., fast and unstable drug release was obtained in the case of low MW PEO 750 whereas stable drug release was obtained in the case of high MW PEO 303. The release of low water-soluble drug zonisamidewas stable regardless of both the presence of vitamin E and the MW of PEO. The presence of vitamin E slightly slowed the release ofzonisamide from aged PEO 303 matrices but not PEO 750 matrices. Therefore, in order to achieve a suitable controlled release profile from PEO matrices, not only the presence of vitamin E but also the solubility of drug and the MW of polyox should be considered.
    Citation
    Investigation of drug release from PEO tablet matrices in the presence of vitamin E as antioxidant. 2015: Curr Drug Deliv
    Publisher
    Bentham Science Publishers
    Journal
    Current drug delivery
    URI
    http://hdl.handle.net/2436/565030
    PubMed ID
    25808280
    Type
    Journal article
    Language
    en
    ISSN
    1875-5704
    Collections
    Research Institute in Healthcare Science

    entitlement

    Related articles

    • Comparative evaluation of drug release from aged prolonged polyethylene oxide tablet matrices: effect of excipient and drug type.
    • Authors: Shojaee S, Kaialy W, Cumming KI, Nokhodchi A
    • Issue date: 2016 Mar
    • Evaluation of the drug solubility and rush ageing on drug release performance of various model drugs from the modified release polyethylene oxide matrix tablets.
    • Authors: Shojaee S, Nokhodchi A, Maniruzzaman M
    • Issue date: 2017 Feb
    • Effects of drug solubility, drug loading, and polymer molecular weight on drug release from Polyox tablets.
    • Authors: Kim CJ
    • Issue date: 1998 Jul
    • An investigation into the stabilization of diltiazem HCl release from matrices made from aged polyox powders.
    • Authors: Shojaee S, Asare-Addo K, Kaialy W, Nokhodchi A, Cumming I
    • Issue date: 2013 Sep
    • Stability of polyethylene oxide in matrix tablets prepared by hot-melt extrusion.
    • Authors: Crowley MM, Zhang F, Koleng JJ, McGinity JW
    • Issue date: 2002 Nov
    DSpace software (copyright © 2002 - 2023)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.