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    An Investigation on the Effect of Polyethylene Oxide Concentration and Particle Size in Modulating Theophylline Release from Tablet Matrices.

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    Authors
    Shojaee, Saeed
    Emami, Parastou
    Mahmood, Ahmad
    Rowaiye, Yemisi
    Dukulay, Alusine
    Kaialy, Waseem
    Cumming, Iain
    Nokhodchi, Ali
    Issue Date
    2015-03-14
    
    Metadata
    Show full item record
    Abstract
    Polyethylene oxide has been researched extensively as an alternative polymer to hydroxypropyl methylcellulose (HPMC) in controlled drug delivery due to its desirable swelling properties and its availability in a number of different viscosity grades. Previous studies on HPMC have pointed out the importance of particle size on drug release, but as of yet, no studies have investigated the effect of particle size of polyethylene oxide (polyox) on drug release. The present study explored the relationship between polymer level and particle size to sustain the drug release. Tablets produced contained theophylline as their active ingredient and consisted of different polyethylene oxide particle size fractions (20-45, 45-90, 90-180 and 180-425 μm). It was shown that matrices containing smaller particle sizes of polyox produced harder tablets than when larger polyox particles were used. The release studies showed that matrices consisting of large polyox particles showed a faster release rate than matrices made from smaller particles. Molecular weight (MW) of the polymer was a key determining step in attaining sustained release, with the high MW of polyox resulting in a delayed release profile. The results showed that the effect of particle size on drug release was more detrimental when a low concentration of polyox was used. This indicates that care must be taken when low levels of polyox with different particle size fractions are used. More robust formulations could be obtained when the concentration of polyox is high. Differential scanning calorimetry (DSC) traces showed that particle size had no major effect on the thermal behaviour of polyox particles.
    Citation
    An Investigation on the Effect of Polyethylene Oxide Concentration and Particle Size in Modulating Theophylline Release from Tablet Matrices. 2015: AAPS PharmSciTech
    Publisher
    Springer
    Journal
    AAPS PharmSciTech
    URI
    http://hdl.handle.net/2436/564206
    DOI
    10.1208/s12249-015-0295-z
    PubMed ID
    25771738
    Type
    Journal article
    Language
    en
    ISSN
    1530-9932
    ae974a485f413a2113503eed53cd6c53
    10.1208/s12249-015-0295-z
    Scopus Count
    Collections
    Research Institute in Healthcare Science

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