Antisolvent precipitation of novel xylitol-additive crystals to engineer tablets with improved pharmaceutical performance.
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
MetadataShow full item record
AbstractThe purpose of this work was to develop stable xylitol particles with modified physical properties, improved compactibility and enhanced pharmaceutical performance without altering polymorphic form of xylitol. Xylitol was crystallized using antisolvent crystallization technique in the presence of various hydrophilic polymer additives, i.e., polyethylene glycol (PEG), polyvinylpyrrolidone (PVP) and polyvinyl alcohol (PVA) at a range of concentrations. The crystallization process did not influence the stable polymorphic form or true density of xylitol. However, botryoidal-shaped crystallized xylitols demonstrated different particle morphologies and lower powder bulk and tap densities in comparison to subangular-shaped commercial xylitol. Xylitol crystallized without additive and xylitol crystallized in the presence of PVP or PVA demonstrated significant improvement in hardness of directly compressed tablets; however, such improvement was observed to lesser extent for xylitol crystallized in the presence of PEG. Crystallized xylitols produced enhanced dissolution profiles for indomethacin in comparison to original xylitol. The influence of additive concentration on tablet hardness was dependent on the type of additive, whereas an increased concentration of all additives provided an improvement in the dissolution behavior of indomethacin. Antisolvent crystallization using judiciously selected type and concentration of additive can be a potential approach to prepare xylitol powders with promising physicomechanical and pharmaceutical properties.
CitationAntisolvent precipitation of novel xylitol-additive crystals to engineer tablets with improved pharmaceutical performance. 2014, 477 (1-2):282-93 Int J Pharm
JournalInternational journal of pharmaceutics
- Antisolvent precipitation technique: A very promising approach to crystallize curcumin in presence of polyvinyl pyrrolidon for solubility and dissolution enhancement.
- Authors: Sadeghi F, Ashofteh M, Homayouni A, Abbaspour M, Nokhodchi A, Garekani HA
- Issue date: 2016 Nov 1
- An approach to engineer paracetamol crystals by antisolvent crystallization technique in presence of various additives for direct compression.
- Authors: Kaialy W, Larhrib H, Chikwanha B, Shojaee S, Nokhodchi A
- Issue date: 2014 Apr 10
- Development of spray-dried co-precipitate of amorphous celecoxib containing storage and compression stabilizers.
- Authors: Dhumal RS, Shimpi SL, Paradkar AR
- Issue date: 2007 Sep
- Evaluation of tableting and tablet properties of Kollidon SR: the influence of moisture and mixtures with theophylline monohydrate.
- Authors: Hauschild K, Picker-Freyer KM
- Issue date: 2006 Feb
- Influence of excipients on solubility and dissolution of pharmaceuticals.
- Authors: Paus R, Prudic A, Ji Y
- Issue date: 2015 May 15