Prevalence and associations of hypertension and its control in patients with rheumatoid arthritis.
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
AuthorsPanoulas, Vasileios F.
Douglas, Karen M. J.
Milionis, Haralampos J.
Kita, Marina D.
Tselios, Andreas L.
Metsios, Giorgos S.
Elisaf, Moses S.
Kitas, George D.
MetadataShow full item record
AbstractOBJECTIVES: Rheumatoid arthritis (RA) associates with excessive cardiovascular morbidity and mortality. Hypertension (HT) contributes significantly to the development of cardiovascular disease (CVD). Little is known about the factors that influence blood pressure (BP) in patients with RA. In this study, we assessed the prevalence of HT in a secondary care cohort of RA patients, and aimed to identify factors associated with its presence and inadequate control. METHODS: A total of 400 consecutive RA patients were studied. HT was defined as systolic BP >/=140 mmHg and/or diastolic BP >/=90 mmHg or current use of antihypertensive drugs. The association of HT with several demographic and RA-related factors, comorbidities and drugs was evaluated using logistic regression. RESULTS: HT was present in 282 (70.5%) patients. Of those, 171 (60.6%) received anti-hypertensive therapy, but 111 (39.4%) remained undiagnosed. Of those treated, only 37/171 (21.8%) were optimally controlled. Multivariable logistic regression revealed age (OR = 1.054, CI: 1.02 to 1.07, P = 0.001), body mass index [BMI (OR = 1.06, CI: 1.003-1.121, P = 0.038)] and prednisolone use (OR = 2.39, CI: 1.02-5.6, P = 0.045) to be independently associated with the presence of HT. BMI (OR = 1.11, CI: 1.02-1.21, P = 0.002) and the presence of CVD (OR = 4.01, CI: 1.27-12.69, P = 0.018) associated with uncontrolled HT. CONCLUSIONS: HT is highly prevalent in RA, under-diagnosed particularly in the young, and under-treated particularly in old RA patients with CVD. RA patients receiving steroids should be specifically targeted for screening and treatment; those with any cardiovascular comorbidity may require particularly aggressive monitoring and treatment strategies.
CitationRheumatology, 46 (9): 1477-82
PublisherOxford University Press
DescriptionThis is a pre-copy-editing, author-produced PDF of an article accepted for publication in Rheumatology following peer review. The definitive publisher-authenticated version in Rheumatology 2007 46(9), 1477-1482, is available online at the links given above.
- Prevalence of prehypertension and hypertension and associated risk factors among Turkish adults: Trabzon Hypertension Study.
- Authors: Erem C, Hacihasanoglu A, Kocak M, Deger O, Topbas M
- Issue date: 2009 Mar
- Serum uric acid is independently associated with hypertension in patients with rheumatoid arthritis.
- Authors: Panoulas VF, Douglas KM, Milionis HJ, Nightingale P, Kita MD, Klocke R, Metsios GS, Stavropoulos-Kalinoglou A, Elisaf MS, Kitas GD
- Issue date: 2008 Mar
- [Hypertension in hemodialysis patients in Andalucia].
- Authors: García Cortés MJ, Ceballos M, Grupo de tabajo sobre Calidad de la Hemodiálisis en Andalucía.
- Issue date: 2004
- Metabolic disorders associated with uncontrolled hypertension.
- Authors: Bøg-Hansen E, Lindblad U, Gullberg B, Melander A, Råstam L
- Issue date: 2003 Nov
- Immunosuppressive medications and hospitalization for cardiovascular events in patients with rheumatoid arthritis.
- Authors: Solomon DH, Avorn J, Katz JN, Weinblatt ME, Setoguchi S, Levin R, Schneeweiss S
- Issue date: 2006 Dec