Show simple item record

dc.contributor.authorFlouris, Andreas D.
dc.contributor.authorMetsios, Giorgos S.
dc.contributor.authorJamurtas, Athanasios Z.
dc.contributor.authorKoutedakis, Yiannis
dc.date.accessioned2008-10-30T22:36:17Z
dc.date.available2008-10-30T22:36:17Z
dc.date.issued2008
dc.identifier.citationAmerican Journal of Physiology, 294(2): E456-462
dc.identifier.issn0193-1849
dc.identifier.pmid18073318
dc.identifier.doi10.1152/ajpendo.00699.2007
dc.identifier.urihttp://hdl.handle.net/2436/39977
dc.description.abstractExperimental evidence for the physiological effects of secondhand smoke (SHS) is limited, although it affects millions of people globally and its prevalence is increasing, despite currently adopted antismoking measures. Also, scarce evidence suggests that the effects of SHS may be more pronounced in men. We conducted a randomized single-blind crossover study to investigate the sex-specific SHS effects in a controlled simulated bar/restaurant environment on gonadal and thyroid hormones, inflammatory cytokines, and vascular function. Twenty-eight (women = 14) nonsmoking adults underwent a 1-h exposure to moderate SHS and a 1-h control trial. Serum and urine cotinine, gonadal and thyroid hormones, inflammatory cytokines, heart rate, and arterial blood pressure were assessed before exposure and immediately after in both trials. Results showed that testosterone (P = 0.019) and progesterone (P < 0.001) in men and 17beta-estradiol (P = 0.001) and progesterone (P < 0.001) in women were significantly decreased after SHS. In men, SHS was accompanied by increased free thyroxine (P < 0.001), triiodothyronine (P = 0.020), and decreased the triiodothyronine-to-free thyroxine ratio (P = 0.033). In women, significant SHS-induced change was observed only in free thyroxine (P = 0.010), with considerable sex variation in free thyroxine and triiodothyronine and a decrease in luteinizing hormone (P = 0.026) and follicle-stimulating hormone (P < 0.001). After SHS, IL-1beta (P = 0.001) and systolic blood pressure (P = 0.040) were increased in men but not women. We concluded that a 1-h SHS exposure at bar/restaurant levels is accompanied by decrements in gonadal hormones in both sexes and marked increases in thyroid hormone secretion, IL-1beta production, and systolic blood pressure in men.
dc.language.isoen
dc.publisherAmerican Physiological Society
dc.relation.urlhttp://ajpendo.physiology.org/cgi/content/abstract/294/2/E456
dc.subjectCigarette smoking
dc.subjectEnvironmental Tobacco Smoke
dc.subjectEstrogen
dc.subjectCytokines
dc.subject.meshAdult
dc.subject.meshBlood Pressure
dc.subject.meshCardiovascular System
dc.subject.meshCotinine
dc.subject.meshCross-Over Studies
dc.subject.meshEstradiol
dc.subject.meshFemale
dc.subject.meshFollicle Stimulating Hormone
dc.subject.meshHeart Rate
dc.subject.meshHumans
dc.subject.meshImmunity
dc.subject.meshInflammation Mediators
dc.subject.meshInterleukin-1beta
dc.subject.meshInterleukin-6
dc.subject.meshLuteinizing Hormone
dc.subject.meshMale
dc.subject.meshRegression Analysis
dc.subject.meshSex Characteristics
dc.subject.meshSingle-Blind Method
dc.subject.meshTestosterone
dc.subject.meshThyroid Hormones
dc.subject.meshTobacco Smoke Pollution
dc.subject.meshTumor Necrosis Factor-alpha
dc.titleSexual dimorphism in the acute effects of secondhand smoke on thyroid hormone secretion, inflammatory markers and vascular function.
dc.typeJournal article
dc.identifier.journalAmerican Journal of Physiology
html.description.abstractExperimental evidence for the physiological effects of secondhand smoke (SHS) is limited, although it affects millions of people globally and its prevalence is increasing, despite currently adopted antismoking measures. Also, scarce evidence suggests that the effects of SHS may be more pronounced in men. We conducted a randomized single-blind crossover study to investigate the sex-specific SHS effects in a controlled simulated bar/restaurant environment on gonadal and thyroid hormones, inflammatory cytokines, and vascular function. Twenty-eight (women = 14) nonsmoking adults underwent a 1-h exposure to moderate SHS and a 1-h control trial. Serum and urine cotinine, gonadal and thyroid hormones, inflammatory cytokines, heart rate, and arterial blood pressure were assessed before exposure and immediately after in both trials. Results showed that testosterone (P = 0.019) and progesterone (P < 0.001) in men and 17beta-estradiol (P = 0.001) and progesterone (P < 0.001) in women were significantly decreased after SHS. In men, SHS was accompanied by increased free thyroxine (P < 0.001), triiodothyronine (P = 0.020), and decreased the triiodothyronine-to-free thyroxine ratio (P = 0.033). In women, significant SHS-induced change was observed only in free thyroxine (P = 0.010), with considerable sex variation in free thyroxine and triiodothyronine and a decrease in luteinizing hormone (P = 0.026) and follicle-stimulating hormone (P < 0.001). After SHS, IL-1beta (P = 0.001) and systolic blood pressure (P = 0.040) were increased in men but not women. We concluded that a 1-h SHS exposure at bar/restaurant levels is accompanied by decrements in gonadal hormones in both sexes and marked increases in thyroid hormone secretion, IL-1beta production, and systolic blood pressure in men.


This item appears in the following Collection(s)

Show simple item record