• Plasma irisin levels predict telomere length in healthy adults

      Rana, Karan S.; Arif, Mohammed; Hill, Eric J.; Aldred, Sarah; Nagel, David A.; Nevill, Alan M.; Randeva, Harpal S.; Bailey, Clifford J.; Bellary, Srikanth; Brown, James E. (Springer Verlag, 2014-01-29)
      The ageing process is strongly influenced by nutrient balance, such that modest calorie restriction (CR) extends lifespan in mammals. Irisin, a newly described hormone released from skeletal muscles after exercise, may induce CR-like effects by increasing adipose tissue energy expenditure. Using telomere length as a marker of ageing, this study investigates associations between body composition, plasma irisin levels and peripheral blood mononuclear cell telomere length in healthy, non-obese individuals. Segmental body composition (by bioimpedance), telomere length and plasma irisin levels were assessed in 81 healthy individuals (age 43±15.8 years, BMI 24.3±2.9 kg/m2). Data showed significant correlations between log-transformed relative telomere length and the following: age (p<0.001), height (p=0.045), total body fat percentage (p=0.031), abdominal fat percentage (p=0.038), visceral fat level (p<0.001), plasma leptin (p=0.029) and plasma irisin (p=0.011), respectively. Multiple regression analysis using backward elimination revealed that relative telomere length can be predicted by age (b=−0.00735, p= 0.001) and plasma irisin levels (b=0.04527, p=0.021). These data support the view that irisin may have a role in the modulation of both energy balance and the ageing process.