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Rheumatoid Arthritis is Associated with IgG Antibodies to Human Endogenous Retrovirus Gag Matrix: A Potential Pathogenic Mechanism of Disease?

dc.contributor.authorNelson, Paul N
dc.contributor.authorRoden, Denise
dc.contributor.authorNevill, Alan M.
dc.contributor.authorFreimanis, Graham L
dc.contributor.authorTrela, Malgorzata
dc.contributor.authorEjtehadi, Hora Davari
dc.contributor.authorBowman, Simon
dc.contributor.authorAxford, John
dc.contributor.authorVeitch, Andy M
dc.contributor.authorTugnet, Nicola
dc.contributor.authorRylance, Paul B
dc.date.accessioned2014-11-03T12:17:37Z
dc.date.available2014-11-03T12:17:37Z
dc.date.issued2014-10
dc.identifier.citationRheumatoid Arthritis is Associated with IgG Antibodies to Human Endogenous Retrovirus Gag Matrix: A Potential Pathogenic Mechanism of Disease? 2014, 41 (10):1952-60 J. Rheumatol.en_GB
dc.identifier.issn0315-162X
dc.identifier.pmid25225282
dc.identifier.doi10.3899/jrheum.130502
dc.identifier.urihttp://hdl.handle.net/2436/333571
dc.description.abstractHuman endogenous retrovirus (HERV)-K10 has been implicated in the etiology and pathogenesis of rheumatoid arthritis (RA). A secondary immune response to this virus might suggest an antigen-driven response in patients. The Gag region of HERV-K10 could provide a key epitope important for immunological reactivity. We investigated the presence of IgG antibodies to this region and assessed its significance in RA.
dc.language.isoenen
dc.rightsArchived with thanks to The Journal of rheumatologyen_GB
dc.subjectRHEUMATOID ARTHRITISen_GB
dc.subjectENZYME LINKED IMMUNOSORBENT ASSAYen_GB
dc.subjectHUMAN ENDOGENOUS RETROVIRUSen_GB
dc.subjectBIOINFORMATICSen_GB
dc.titleRheumatoid Arthritis is Associated with IgG Antibodies to Human Endogenous Retrovirus Gag Matrix: A Potential Pathogenic Mechanism of Disease?en
dc.typeJournal article
dc.identifier.journalThe Journal of rheumatologyen_GB
dc.source.volume41
dc.source.issue10
dc.source.beginpage1952
dc.source.endpage1960
html.description.abstractHuman endogenous retrovirus (HERV)-K10 has been implicated in the etiology and pathogenesis of rheumatoid arthritis (RA). A secondary immune response to this virus might suggest an antigen-driven response in patients. The Gag region of HERV-K10 could provide a key epitope important for immunological reactivity. We investigated the presence of IgG antibodies to this region and assessed its significance in RA.


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