Rheumatoid Arthritis is Associated with IgG Antibodies to Human Endogenous Retrovirus Gag Matrix: A Potential Pathogenic Mechanism of Disease?
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Authors
Nelson, Paul NRoden, Denise
Nevill, Alan M.
Freimanis, Graham L
Trela, Malgorzata
Ejtehadi, Hora Davari
Bowman, Simon
Axford, John
Veitch, Andy M
Tugnet, Nicola
Rylance, Paul B
Issue Date
2014-10
Metadata
Show full item recordAbstract
Human endogenous retrovirus (HERV)-K10 has been implicated in the etiology and pathogenesis of rheumatoid arthritis (RA). A secondary immune response to this virus might suggest an antigen-driven response in patients. The Gag region of HERV-K10 could provide a key epitope important for immunological reactivity. We investigated the presence of IgG antibodies to this region and assessed its significance in RA.Citation
Rheumatoid Arthritis is Associated with IgG Antibodies to Human Endogenous Retrovirus Gag Matrix: A Potential Pathogenic Mechanism of Disease? 2014, 41 (10):1952-60 J. Rheumatol.Journal
The Journal of rheumatologyPubMed ID
25225282Type
ArticleLanguage
enISSN
0315-162Xae974a485f413a2113503eed53cd6c53
10.3899/jrheum.130502
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