Rheumatoid Arthritis is Associated with IgG Antibodies to Human Endogenous Retrovirus Gag Matrix: A Potential Pathogenic Mechanism of Disease?

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Authors
Nelson, Paul N
Roden, Denise
Nevill, Alan M.
Freimanis, Graham L
Trela, Malgorzata
Ejtehadi, Hora Davari
Bowman, Simon
Axford, John
Veitch, Andy M
Tugnet, Nicola
Issue Date
2014-10

Metadata
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Abstract
Human endogenous retrovirus (HERV)-K10 has been implicated in the etiology and pathogenesis of rheumatoid arthritis (RA). A secondary immune response to this virus might suggest an antigen-driven response in patients. The Gag region of HERV-K10 could provide a key epitope important for immunological reactivity. We investigated the presence of IgG antibodies to this region and assessed its significance in RA.
Citation
Rheumatoid Arthritis is Associated with IgG Antibodies to Human Endogenous Retrovirus Gag Matrix: A Potential Pathogenic Mechanism of Disease? 2014, 41 (10):1952-60 J. Rheumatol.
Journal
The Journal of rheumatology
URI
http://hdl.handle.net/2436/333571
DOI
10.3899/jrheum.130502
PubMed ID
25225282
Type
Journal article
Language
en
ISSN
0315-162X
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