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dc.contributor.authorRana, Karan S.
dc.contributor.authorArif, Mohammed
dc.contributor.authorHill, Eric J.
dc.contributor.authorAldred, Sarah
dc.contributor.authorNagel, David A.
dc.contributor.authorNevill, Alan M.
dc.contributor.authorRandeva, Harpal S.
dc.contributor.authorBailey, Clifford J.
dc.contributor.authorBellary, Srikanth
dc.contributor.authorBrown, James E.
dc.date.accessioned2014-02-27T11:54:59Z
dc.date.available2014-02-27T11:54:59Z
dc.date.issued2014-04
dc.identifier.citationPlasma irisin levels predict telomere length in healthy adults 2014 AGE
dc.identifier.issn0161-9152
dc.identifier.issn1574-4647
dc.identifier.doi10.1007/s11357-014-9620-9
dc.identifier.urihttp://hdl.handle.net/2436/313455
dc.description.abstractThe ageing process is strongly influenced by nutrient balance, such that modest calorie restriction (CR) extends lifespan in mammals. Irisin, a newly described hormone released from skeletal muscles after exercise, may induce CR-like effects by increasing adipose tissue energy expenditure. Using telomere length as a marker of ageing, this study investigates associations between body composition, plasma irisin levels and peripheral blood mononuclear cell telomere length in healthy, non-obese individuals. Segmental body composition (by bioimpedance), telomere length and plasma irisin levels were assessed in 81 healthy individuals (age 43±15.8 years, BMI 24.3±2.9 kg/m2). Data showed significant correlations between log-transformed relative telomere length and the following: age (p<0.001), height (p=0.045), total body fat percentage (p=0.031), abdominal fat percentage (p=0.038), visceral fat level (p<0.001), plasma leptin (p=0.029) and plasma irisin (p=0.011), respectively. Multiple regression analysis using backward elimination revealed that relative telomere length can be predicted by age (b=−0.00735, p= 0.001) and plasma irisin levels (b=0.04527, p=0.021). These data support the view that irisin may have a role in the modulation of both energy balance and the ageing process.
dc.language.isoen
dc.publisherSpringer Verlag
dc.relation.urlhttp://link.springer.com/10.1007/s11357-014-9620-9
dc.subjectIrisin
dc.subjectTelomere length
dc.subjectAgeing
dc.subjectBody composition
dc.subjectAdipose tissue
dc.subjectMuscle
dc.titlePlasma irisin levels predict telomere length in healthy adults
dc.typeArticle
dc.identifier.journalAge
refterms.dateFOA2018-08-21T11:04:22Z
html.description.abstractThe ageing process is strongly influenced by nutrient balance, such that modest calorie restriction (CR) extends lifespan in mammals. Irisin, a newly described hormone released from skeletal muscles after exercise, may induce CR-like effects by increasing adipose tissue energy expenditure. Using telomere length as a marker of ageing, this study investigates associations between body composition, plasma irisin levels and peripheral blood mononuclear cell telomere length in healthy, non-obese individuals. Segmental body composition (by bioimpedance), telomere length and plasma irisin levels were assessed in 81 healthy individuals (age 43±15.8 years, BMI 24.3±2.9 kg/m2). Data showed significant correlations between log-transformed relative telomere length and the following: age (p<0.001), height (p=0.045), total body fat percentage (p=0.031), abdominal fat percentage (p=0.038), visceral fat level (p<0.001), plasma leptin (p=0.029) and plasma irisin (p=0.011), respectively. Multiple regression analysis using backward elimination revealed that relative telomere length can be predicted by age (b=−0.00735, p= 0.001) and plasma irisin levels (b=0.04527, p=0.021). These data support the view that irisin may have a role in the modulation of both energy balance and the ageing process.


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