Authors
Rana, Karan S.Arif, Mohammed
Hill, Eric J.
Aldred, Sarah
Nagel, David A.
Nevill, Alan M.
Randeva, Harpal S.
Bailey, Clifford J.
Bellary, Srikanth
Brown, James E.
Issue Date
2014-01-29
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Show full item recordAbstract
The ageing process is strongly influenced by nutrient balance, such that modest calorie restriction (CR) extends lifespan in mammals. Irisin, a newly described hormone released from skeletal muscles after exercise, may induce CR-like effects by increasing adipose tissue energy expenditure. Using telomere length as a marker of ageing, this study investigates associations between body composition, plasma irisin levels and peripheral blood mononuclear cell telomere length in healthy, non-obese individuals. Segmental body composition (by bioimpedance), telomere length and plasma irisin levels were assessed in 81 healthy individuals (age 43±15.8 years, BMI 24.3±2.9 kg/m2). Data showed significant correlations between log-transformed relative telomere length and the following: age (p<0.001), height (p=0.045), total body fat percentage (p=0.031), abdominal fat percentage (p=0.038), visceral fat level (p<0.001), plasma leptin (p=0.029) and plasma irisin (p=0.011), respectively. Multiple regression analysis using backward elimination revealed that relative telomere length can be predicted by age (b=−0.00735, p= 0.001) and plasma irisin levels (b=0.04527, p=0.021). These data support the view that irisin may have a role in the modulation of both energy balance and the ageing process.Citation
Plasma irisin levels predict telomere length in healthy adults 2014 AGEPublisher
Springer VerlagJournal
AgeAdditional Links
http://link.springer.com/10.1007/s11357-014-9620-9Type
Journal articleLanguage
enISSN
0161-91521574-4647
ae974a485f413a2113503eed53cd6c53
10.1007/s11357-014-9620-9
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Except where otherwise noted, this item's license is described as https://creativecommons.org/licenses/by/4.0/