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    Human endogenous retrovirus HERV-K10 implicated in rheumatoid arthritis and systemic lupus erythematosus: potential pathological triggers?

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    Nelson 29-30 2006
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    Authors
    Nelson, Paul N.
    Shaw, M.
    Roden, Denise A.
    Freimanis, Graham L.
    Nevill, Alan M.
    Rylance, Paul
    Issue Date
    2006
    
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    Show full item record
    Other Titles
    In: The 33rd Congress of the Czech Society of Pathologists, 2nd Satellite Symposium & Workshop on Molecular Pathology, Regional Centre Olomouc & Faculty of Medicine, Palacky University Olomouc, May 4–6, 2006, 29-30.
    Abstract
    Human endogenous retroviruses (HERVs) are a group of integrated RNA viruses within our human genome. Whilst many are regarded as defective, a number possess the potential to generate retroviral products. Indeed HERVs such as those belonging to the HERV-K family produce retroviral particles in the teratocarcinoma cell line GH and the breast cancer cell line T47D. It has been argued that some retroelements may be beneficial to the human host, perhaps conferring a selective advantage, whereas others may be harmful. Furthermore certain HERVs might be involved in the pathogenesis of autoimmune diseases. The precise mechanisms in diseases such as rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) may include molecular mimicry and superantigen motifs that evoke and augment unwarranted immune responses. The precise mechanisms in diseases such as rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) may include molecular mimicry and superantigen motifs that evoke and augment unwarranted immune responses. In the RA joint, tissue destruction is evident over time with recruitment of lymphoid and other cells plus the presence of rheumatoid factor that exhibits increased affinity and change in isotype; evidence of an antigen-driven immune response. The precise trigger of course, remains unknown although certain HERVs have been implicated. In a previous study we found evidence for increased expression of HERV-K10 mRNA in patients with RA. Here we have extended this work by investigating the serological expression to HERV-K10 in patients with RA, SLE, osteoarthritis, normals and other inflammatory disease groups. The study utilised a novel peptide ELISA immunoassay using segments of HERV-K10 identified through bioinformatic analysis. In particular, biotinylation of peptides was necessary for serological discrimination between patients. Overall a significant difference (p<0.05) was found for RA patients in terms of antibody activity to HERV-K10. There was also an increased level of antibodies to HERV-K10 in patients with renal lupus although this was below the level of significance. It is possible that HERV-K10 could act as a trigger in RA/SLE through regions of similarity to host proteins. In this case, the immune response to HERV-K10 could lead to collateral damage and pathogenesis of disease.
    Citation
    Biomedical Papers, 150(Suppl 1): 29-30
    Publisher
    Czech Republic: Palacky University, Olomouc: Faculty of Medicine and Dentistry
    Journal
    Biomedical Papers
    URI
    http://hdl.handle.net/2436/30252
    Additional Links
    http://publib.upol.cz/~obd/fulltext/Biomed/2006/Suppl.1/1.pdf
    Type
    Conference contribution
    Language
    en
    Description
    Abstract is provided here courtesy of Palacky University, Olomouc.
    ISSN
    1213-8118
    Collections
    Research Institute in Healthcare Science

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