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    Vascular endothelial growth factor in astroglioma stem cell biology and response to therapy

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    Authors
    Knizetova, Petra
    Darling, John L.
    Bartek, Jiri
    Issue Date
    2008
    
    Metadata
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    Abstract
    Malignant astrogliomas are among the most aggressive, highly vascular and infiltrating tumours bearing a dismal prognosis, mainly due to their resistance to current radiation treatment and chemotherapy. Efforts to identify and target the mechanisms that underlie astroglioma resistance have recently focused on candidate cancer stem cells, their biological properties, interplay with their local microenvironment or 'niche', and their role in tumour progression and recurrence. Both paracrine and autocrine regulation of astroglioma cell behaviour by locally produced cytokines such as the vascular endothelial growth factor (VEGF) are emerging as key factors that determine astroglioma cell fate. Here, we review these recent rapid advances in astroglioma research, with emphasis on the significance of VEGF in astroglioma stem-like cell biology. Furthermore, we highlight the unique DNA damage checkpoint properties of the CD133-marker-positive astroglioma stem-like cells, discuss their potential involvement in astroglioma radioresistance, and consider the implications of this new knowledge for designing combinatorial, more efficient therapeutic strategies.
    Citation
    Journal of Cellular and Molecular Medicine, 12(1): 111-125
    Publisher
    Wiley InterScience
    Journal
    Journal of Cellular and Molecular Medicine
    URI
    http://hdl.handle.net/2436/29814
    DOI
    10.1111/j.1582-4934.2007.00153.x
    PubMed ID
    18031298
    Additional Links
    http://www3.interscience.wiley.com/journal/119424038/abstract.x
    Type
    Journal article
    Language
    en
    ISSN
    1582-1838
    ae974a485f413a2113503eed53cd6c53
    10.1111/j.1582-4934.2007.00153.x
    Scopus Count
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    Research Institute in Healthcare Science

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