• Admin Login
    View Item 
    •   Home
    • Research Institute in Healthcare Science
    • Research Institute in Healthcare Science
    • View Item
    •   Home
    • Research Institute in Healthcare Science
    • Research Institute in Healthcare Science
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of WIRECommunitiesTitleAuthorsIssue DateSubmit DateSubjectsTypesJournalDepartmentPublisherThis CollectionTitleAuthorsIssue DateSubmit DateSubjectsTypesJournalDepartmentPublisher

    Administrators

    Admin Login

    Local Links

    AboutThe University LibraryOpen Access Publications PolicyDeposit LicenceCOREWIRE Copyright and Reuse Information

    Statistics

    Display statistics

    Response of short-term cultures derived from human malignant glioma to aziridinylbenzoquinone, etoposide and doxorubicin: an in vitro phase II trial.

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Authors
    Darling, John L.
    Thomas, David G.
    Issue Date
    2001
    
    Metadata
    Show full item record
    Abstract
    The relative resistance of malignant glioma to chemotherapy makes the identification of new cytotoxic drugs critically important. The use of short-term cultures derived from these tumors to screen drugs at doses that can be attained within human intracranial tumors provides a model system that should be capable of identifying effective drugs suitable for clinical evaluation. The sensitivity of a panel of short-term cultures derived from 22 malignant astrocytoma and four malignant oligodendroglioma was assessed to aziridinylbenzoquinone (AZQ), etoposide and doxorubicin (DOX) using a [(35)S] methione uptake assay. The ID(50) of each culture was compared to the levels of drug which could be achieved in the tumor using standard doses. There was marked heterogeneity between cultures in response to each drug. Whilst there was no evidence that cultures derived from grade III astrocytoma were more sensitive to any of the drugs than cultures derived from grade IV astrocytoma, cultures derived from oligodendroglioma tended to be more sensitive to the alkylating agent AZQ, but not to either of the other drugs. The sensitivity of these short-term cultures at concentrations that can be achieved in situ corresponded well with the clinical efficacy of AZQ and etoposide. Although DOX appeared to be toxic to human gliomas cells in vitro, its limited penetration into the intact brain would seem to preclude its use i.v., but it is likely to be effective if local drug delivery techniques could be employed. The study suggests that short-term cultures derived from malignant glioma should be used to screen investigational agents for potential clinical efficacy.
    Citation
    Anti-cancer Drugs, 12 (9): 753-760
    Publisher
    Lippincott Williams & Wilkins, Inc.
    Journal
    Anti-cancer Drugs
    URI
    http://hdl.handle.net/2436/29812
    PubMed ID
    11593057
    Additional Links
    http://www.anti-cancerdrugs.com/pt/re/anticd/abstract.00001813-200110000-00007.htm;jsessionid=LTWhTW6qcGpXJWyLzKtJVTbLqjDGV1l7TlZhXc2h2KJHmTcrgQyr!-471255264!181195629!8091!-1
    Type
    Journal article
    Language
    en
    ISSN
    0959-4973
    Collections
    Research Institute in Healthcare Science

    entitlement

    Related articles

    • Phase II study of aziridinylbenzoquinone (AZQ: NSC-182986) in the treatment of malignant gliomas recurrent after radiation. Preliminary report.
    • Authors: Decker DA, Al Sarraf M, Kresge C, Austin D, Wilner HI
    • Issue date: 1985
    • Response variability of human brain tumors to AZQ in tissue culture.
    • Authors: Kornblith PL, Rosa L, Bona JD, Edwards JA, Matuzic N, Hirschfeld A, Hawkins C
    • Issue date: 1986
    • Aziridinylbenzoquinone (AZQ) in the treatment of recurrent pediatric brain and other malignant solid tumors. A Pediatric Oncology Group phase II study.
    • Authors: Castleberry RP, Ragab AH, Steuber CP, Kamen B, Toledano S, Starling K, Norris D, Burger P, Krischer JP
    • Issue date: 1990 Nov
    • Response rate and toxicity with aziridinylbenzoquinone in patients with recurrent gliomas. A progress report.
    • Authors: Tapazoglou E, Kish J, Ensley J, Al-Sarraf M
    • Issue date: 1988 Aug
    • Sensitivity of short-term cultures derived from human malignant glioma to the anti-cancer drug temozolomide.
    • Authors: Sankar A, Thomas DG, Darling JL
    • Issue date: 1999 Feb
    DSpace software (copyright © 2002 - 2023)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.