Drug resistance in malignant brain tumours

Abstract

THIS BOOK: Major advances have been made in recent years towards understanding the genetic basis of cancer. The molecular events occurring in cancer growth, invasion and its secondary spread are being continually elucidated. This book focuses on these events, the genetics of the disease, the nature and temporal changes of gene expression, and the deregulation of genetic programmes that lie at the root of cancer progression. The authors, experts in their respective fields, have attempted to link the genetic alterations with the biological behaviour of cancers. The discussions, reasoning and inferences are based on the behaviour of a fairly wide spectrum of human cancer, thus greatly augment the potential applicability and value of the postulates to the study and treatment of the disease. The construction of molecular profiles of progression might lead to the identification of reliable markers and chemotherapeutic targets and in this way aid in the treatment and management of patients. This book presents comprehensive accounts that would be useful to research workers in the fields of cancer biology, genetics and molecular biology, clinical and medical oncologists, and will be of interest also to graduate and post-graduate students.