Other TitlesIn: Cell Penetrating Peptides, A Biochemical Society Focused Meeting, University of Wolverhampton, Telford, UK, 9–11 May 2007.
AbstractStudies of CPPs (cell-penetrating peptides), sequences that are also commonly designated as protein transduction domains, now extend to a second decade of exciting and far-reaching discoveries. CPPs are proven vehicles for the intracellular delivery of macromolecules that include oligonucleotides, peptides and proteins, low-molecular-mass drugs, nanoparticles and liposomes. The biochemical properties of different classes of CPP, including various sequences derived from the HIV-1 Tat (transactivator of transcription) [e.g. Tat-(48-60), GRKKRRQRRRPPQ], and the homeodomain of the Drosophila homeoprotein Antennapaedia (residues 43-58, commonly named penetratin, RQIKIWFQNRRMKWKK), also provide novel insights into the fundamental mechanisms of translocation across biological membranes. Thus the efficacy of CPP-mediated cargo delivery continues to provide valuable tools for biomedical research and, as witnessed in 2007, candidate and emerging therapeutics. Thus it is anticipated that the further refinement of CPP technologies will provide drug-delivery vectors, cellular imaging tools, nanoparticulate devices and molecular therapeutics that will have a positive impact on the healthcare arena. The intention of this article is to provide both a succinct overview of current developments and applications of CPP technologies, and to illustrate key developments that the concerted efforts of the many researchers contributing to the Biochemical Society's Focused Meeting in Telford predict for the future. The accompanying papers in this issue of Biochemical Society Transactions provide additional details and appropriate references. Hopefully, the important and eagerly anticipated biomedical and clinical developments within the CPP field will occur sooner rather than later.
CitationBiochemical Society Transactions, 35(4): 767-769
JournalBiochemical Society Transactions
DescriptionThe published full text version of this record is available at the additional link above.
- Cell-penetrating peptides in drug development: enabling intracellular targets.
- Authors: Chen L, Harrison SD
- Issue date: 2007 Aug
- Transport molecules using reverse sequence HIV-Tat polypeptides: not just any old Tat? (WO200808225).
- Authors: Howl J, Jones S
- Issue date: 2009 Sep
- Recent advances in the use of cell-penetrating peptides for medical and biological applications.
- Authors: Fonseca SB, Pereira MP, Kelley SO
- Issue date: 2009 Sep 30
- Chances and pitfalls of cell penetrating peptides for cellular drug delivery.
- Authors: Tréhin R, Merkle HP
- Issue date: 2004 Sep
- Cell-penetrating peptides: Nanocarrier for macromolecule delivery in living cells.
- Authors: Chugh A, Eudes F, Shim YS
- Issue date: 2010 Mar