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    The many futures for cell-penetrating peptides: how soon is now?

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    Authors
    Howl, John D.
    Nicholl, Iain D.
    Jones, Sarah
    Issue Date
    2007
    
    Metadata
    Show full item record
    Other Titles
    In: Cell Penetrating Peptides, A Biochemical Society Focused Meeting, University of Wolverhampton, Telford, UK, 9–11 May 2007.
    Abstract
    Studies of CPPs (cell-penetrating peptides), sequences that are also commonly designated as protein transduction domains, now extend to a second decade of exciting and far-reaching discoveries. CPPs are proven vehicles for the intracellular delivery of macromolecules that include oligonucleotides, peptides and proteins, low-molecular-mass drugs, nanoparticles and liposomes. The biochemical properties of different classes of CPP, including various sequences derived from the HIV-1 Tat (transactivator of transcription) [e.g. Tat-(48-60), GRKKRRQRRRPPQ], and the homeodomain of the Drosophila homeoprotein Antennapaedia (residues 43-58, commonly named penetratin, RQIKIWFQNRRMKWKK), also provide novel insights into the fundamental mechanisms of translocation across biological membranes. Thus the efficacy of CPP-mediated cargo delivery continues to provide valuable tools for biomedical research and, as witnessed in 2007, candidate and emerging therapeutics. Thus it is anticipated that the further refinement of CPP technologies will provide drug-delivery vectors, cellular imaging tools, nanoparticulate devices and molecular therapeutics that will have a positive impact on the healthcare arena. The intention of this article is to provide both a succinct overview of current developments and applications of CPP technologies, and to illustrate key developments that the concerted efforts of the many researchers contributing to the Biochemical Society's Focused Meeting in Telford predict for the future. The accompanying papers in this issue of Biochemical Society Transactions provide additional details and appropriate references. Hopefully, the important and eagerly anticipated biomedical and clinical developments within the CPP field will occur sooner rather than later.
    Citation
    Biochemical Society Transactions, 35(4): 767-769
    Publisher
    Portland Press on behalf of the Biochemical Society
    Journal
    Biochemical Society Transactions
    URI
    http://hdl.handle.net/2436/29794
    DOI
    10.1042/BST0350767
    PubMed ID
    17635144
    Additional Links
    http://www.biochemsoctrans.org/bst/035/bst0350767.htm
    Type
    Journal article
    Language
    en
    Description
    The published full text version of this record is available at the additional link above.
    ISSN
    0300-5127
    1470-8752
    ae974a485f413a2113503eed53cd6c53
    10.1042/BST0350767
    Scopus Count
    Collections
    Research Institute in Healthcare Science

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