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dc.contributor.authorMartin, Jan H.
dc.contributor.authorSymonds, A.
dc.date.accessioned2008-06-10T14:19:01Z
dc.date.available2008-06-10T14:19:01Z
dc.date.issued2002
dc.identifier.citationOncology Reports, 9(2): 379-382
dc.identifier.issn1021-335X
dc.identifier.pmid11836612
dc.identifier.urihttp://hdl.handle.net/2436/29793
dc.description.abstractWe investigated the effect of toremifene, interferon-alpha2a, interferon-alpha2b and interferon-alpha2c, singly and in combination for their effect on the growth of ZR-75-1 human breast cancer cells. Median effect analysis was used to determine synergistic or additive effects. Anti-proliferative studies showed that the growth of ZR-75-1 cells was inhibited to a greater extent by combination treatment with toremifene plus interferon-alpha2a, resulting in a synergistic interaction (CI <1) for all concentrations tested. A combination of toremifene plus interferon-alpha2b resulted in a synergistic interaction (CI <1) for the two highest concentrations of toremifene (10(-6) and 10(-7) M) and an additive effect (CI approximately equal to 1) for the lower concentrations (10(-8) to 10(-10) M). When toremifene was combined with interferon-alpha2c no additive or synergistic interaction was determined.
dc.language.isoen
dc.publisherSpandidos Publications Ltd
dc.relation.urlhttp://www.spandidos.com/or/
dc.subject.meshAntineoplastic Agents, Hormonal
dc.subject.meshAntineoplastic Combined Chemotherapy Protocols
dc.subject.meshBreast Neoplasms
dc.subject.meshCell Division
dc.subject.meshCell Line
dc.subject.meshDose-Response Relationship, Drug
dc.subject.meshDrug Interactions
dc.subject.meshDrug Synergism
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshInterferon Alfa-2a
dc.subject.meshInterferon Alfa-2b
dc.subject.meshInterferon Alfa-2c
dc.subject.meshToremifene
dc.subject.meshTumor Cells, Cultured
dc.titleSynergistic antitumour effect of a combination of toremifene and interferon-alpha on ZR-75-1 human breast cancer cells: dependence on interferon-alpha subtype.
dc.typeJournal article
dc.identifier.journalOncology Reports
html.description.abstractWe investigated the effect of toremifene, interferon-alpha2a, interferon-alpha2b and interferon-alpha2c, singly and in combination for their effect on the growth of ZR-75-1 human breast cancer cells. Median effect analysis was used to determine synergistic or additive effects. Anti-proliferative studies showed that the growth of ZR-75-1 cells was inhibited to a greater extent by combination treatment with toremifene plus interferon-alpha2a, resulting in a synergistic interaction (CI <1) for all concentrations tested. A combination of toremifene plus interferon-alpha2b resulted in a synergistic interaction (CI <1) for the two highest concentrations of toremifene (10(-6) and 10(-7) M) and an additive effect (CI approximately equal to 1) for the lower concentrations (10(-8) to 10(-10) M). When toremifene was combined with interferon-alpha2c no additive or synergistic interaction was determined.


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