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    Synergistic antitumour effect of a combination of toremifene and interferon-alpha on ZR-75-1 human breast cancer cells: dependence on interferon-alpha subtype.

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    Authors
    Martin, Jan H.
    Symonds, A.
    Issue Date
    2002
    
    Metadata
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    Abstract
    We investigated the effect of toremifene, interferon-alpha2a, interferon-alpha2b and interferon-alpha2c, singly and in combination for their effect on the growth of ZR-75-1 human breast cancer cells. Median effect analysis was used to determine synergistic or additive effects. Anti-proliferative studies showed that the growth of ZR-75-1 cells was inhibited to a greater extent by combination treatment with toremifene plus interferon-alpha2a, resulting in a synergistic interaction (CI <1) for all concentrations tested. A combination of toremifene plus interferon-alpha2b resulted in a synergistic interaction (CI <1) for the two highest concentrations of toremifene (10(-6) and 10(-7) M) and an additive effect (CI approximately equal to 1) for the lower concentrations (10(-8) to 10(-10) M). When toremifene was combined with interferon-alpha2c no additive or synergistic interaction was determined.
    Citation
    Oncology Reports, 9(2): 379-382
    Publisher
    Spandidos Publications Ltd
    Journal
    Oncology Reports
    URI
    http://hdl.handle.net/2436/29793
    PubMed ID
    11836612
    Additional Links
    http://www.spandidos.com/or/
    Type
    Journal article
    Language
    en
    ISSN
    1021-335X
    Collections
    Research Institute in Healthcare Science

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