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    Picornavirus uncoating.

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    Authors
    Smyth, M.S.
    Martin, Jan H.
    Issue Date
    2002
    
    Metadata
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    Abstract
    Recently, much has been learned about the molecular mechanisms involved in the pathogenesis of picornaviruses. This has been accelerated by the solving of the crystal structures of many members of this virus family. However, one stage of the virus life cycle remains poorly understood: uncoating. How do these simple but efficient pathogens protect their RNA genomes with a stable protein shell and yet manage to uncoat this genome at precisely the right time during infection? The purpose of this article is to review the current state of knowledge and the most recent theories that attempt to answer this question. The review is based extensively on structural data but also makes reference to the wealth of biochemical information on the topic.
    Citation
    Molecular Pathology, 55(4): 214-219
    Publisher
    British Medical Association
    Journal
    Molecular Pathology
    URI
    http://hdl.handle.net/2436/29792
    PubMed ID
    12147709
    Additional Links
    http://direct.bl.uk/bld/PlaceOrder.do?UIN=117249347&ETOC=RN&from=searchengine
    Type
    Journal article
    Language
    en
    ISSN
    1366-8714
    Collections
    Research Institute in Healthcare Science

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