Abstract
Recently, much has been learned about the molecular mechanisms involved in the pathogenesis of picornaviruses. This has been accelerated by the solving of the crystal structures of many members of this virus family. However, one stage of the virus life cycle remains poorly understood: uncoating. How do these simple but efficient pathogens protect their RNA genomes with a stable protein shell and yet manage to uncoat this genome at precisely the right time during infection? The purpose of this article is to review the current state of knowledge and the most recent theories that attempt to answer this question. The review is based extensively on structural data but also makes reference to the wealth of biochemical information on the topic.Citation
Molecular Pathology, 55(4): 214-219Publisher
British Medical AssociationJournal
Molecular PathologyPubMed ID
12147709Type
Journal articleLanguage
enISSN
1366-8714Collections
Related articles
- Evolution of virulence in picornaviruses.
- Authors: Tracy S, Chapman NM, Drescher KM, Kono K, Tapprich W
- Issue date: 2006
- [Early steps of picornavirus infection].
- Authors: Koike S
- Issue date: 2011 Dec
- Picornavirus uncoating intermediate captured in atomic detail.
- Authors: Ren J, Wang X, Hu Z, Gao Q, Sun Y, Li X, Porta C, Walter TS, Gilbert RJ, Zhao Y, Axford D, Williams M, McAuley K, Rowlands DJ, Yin W, Wang J, Stuart DI, Rao Z, Fry EE
- Issue date: 2013
- Honey Bee Deformed Wing Virus Structures Reveal that Conformational Changes Accompany Genome Release.
- Authors: Organtini LJ, Shingler KL, Ashley RE, Capaldi EA, Durrani K, Dryden KA, Makhov AM, Conway JF, Pizzorno MC, Hafenstein S
- Issue date: 2017 Jan 15
- Picornaviruses.
- Authors: Tuthill TJ, Groppelli E, Hogle JM, Rowlands DJ
- Issue date: 2010