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Down-regulation of nitric oxide production by droloxifene and toremifene in human breast cancer cells.

dc.contributor.authorMartin, Jan H.
dc.contributor.authorSymonds, A.
dc.contributor.authorChohan, S.
dc.date.accessioned2008-06-10T14:12:46Z
dc.date.available2008-06-10T14:12:46Z
dc.date.issued2003
dc.identifier.citationOncology Reports, 10 (4): 979-984
dc.identifier.issn1021-335X
dc.identifier.pmid12792756
dc.identifier.urihttp://hdl.handle.net/2436/29791
dc.description.abstractWe investigated the effect of tamoxifen, 4-OH tamoxifen, toremifene droloxifene, interferon-alpha2a, interferon-alpha2b and interferon-alpha2c, singly and in combination, for their effect on nitric oxide production by MCF-7 and ZR-75-1 human breast cancer cells. Tamoxifen and 4-OH tamoxifen singly had no effect on nitric oxide production by either cell line. However, treatment with droloxifene or toremifene significantly reduced nitric oxide production by both MCF-7 and ZR-75-1 human breast cancer cell lines. Combination treatment with anti-estrogens and interferon-alpha2a interferon-alpha2b or interferon-alpha2c had no synergistic or additive effect compared to each drug singly.
dc.language.isoen
dc.publisherSpandidos Publications Ltd
dc.relation.urlhttp://direct.bl.uk/bld/PlaceOrder.do?UIN=132226908&ETOC=RN&from=searchenginehttp://www.spandidos.com/or/
dc.subject.meshAntineoplastic Combined Chemotherapy Protocols
dc.subject.meshBreast Neoplasms
dc.subject.meshCell Division
dc.subject.meshDose-Response Relationship, Drug
dc.subject.meshDown-Regulation
dc.subject.meshDrug Interactions
dc.subject.meshDrug Synergism
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshInterferon Alfa-2a
dc.subject.meshInterferon Alfa-2b
dc.subject.meshInterferon Alfa-2c
dc.subject.meshNitric Oxide
dc.subject.meshTamoxifen
dc.subject.meshToremifene
dc.subject.meshTumor Cells, Cultured
dc.titleDown-regulation of nitric oxide production by droloxifene and toremifene in human breast cancer cells.
dc.typeJournal article
dc.identifier.journalOncology Reports
html.description.abstractWe investigated the effect of tamoxifen, 4-OH tamoxifen, toremifene droloxifene, interferon-alpha2a, interferon-alpha2b and interferon-alpha2c, singly and in combination, for their effect on nitric oxide production by MCF-7 and ZR-75-1 human breast cancer cells. Tamoxifen and 4-OH tamoxifen singly had no effect on nitric oxide production by either cell line. However, treatment with droloxifene or toremifene significantly reduced nitric oxide production by both MCF-7 and ZR-75-1 human breast cancer cell lines. Combination treatment with anti-estrogens and interferon-alpha2a interferon-alpha2b or interferon-alpha2c had no synergistic or additive effect compared to each drug singly.


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