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    Down-regulation of nitric oxide production by droloxifene and toremifene in human breast cancer cells.

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    Authors
    Martin, Jan H.
    Symonds, A.
    Chohan, S.
    Issue Date
    2003
    
    Metadata
    Show full item record
    Abstract
    We investigated the effect of tamoxifen, 4-OH tamoxifen, toremifene droloxifene, interferon-alpha2a, interferon-alpha2b and interferon-alpha2c, singly and in combination, for their effect on nitric oxide production by MCF-7 and ZR-75-1 human breast cancer cells. Tamoxifen and 4-OH tamoxifen singly had no effect on nitric oxide production by either cell line. However, treatment with droloxifene or toremifene significantly reduced nitric oxide production by both MCF-7 and ZR-75-1 human breast cancer cell lines. Combination treatment with anti-estrogens and interferon-alpha2a interferon-alpha2b or interferon-alpha2c had no synergistic or additive effect compared to each drug singly.
    Citation
    Oncology Reports, 10 (4): 979-984
    Publisher
    Spandidos Publications Ltd
    Journal
    Oncology Reports
    URI
    http://hdl.handle.net/2436/29791
    PubMed ID
    12792756
    Additional Links
    http://direct.bl.uk/bld/PlaceOrder.do?UIN=132226908&ETOC=RN&from=searchenginehttp://www.spandidos.com/or/
    Type
    Journal article
    Language
    en
    ISSN
    1021-335X
    Collections
    Research Institute in Healthcare Science

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