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dc.contributor.authorNelson, Paul N.
dc.contributor.authorHooley, Paul
dc.contributor.authorRoden, Denise A.
dc.contributor.authorEjtehadi, H. Davari
dc.contributor.authorRylance, Paul
dc.contributor.authorWarren, Phil
dc.contributor.authorMartin, Jan H.
dc.contributor.authorMurray, Paul G.
dc.date.accessioned2008-06-10T13:58:28Z
dc.date.available2008-06-10T13:58:28Z
dc.date.issued2004
dc.identifier.citationClinical and Experimental Immunology, 138(1): 1-9
dc.identifier.issn0009-9104
dc.identifier.pmid15373898
dc.identifier.doi10.1111/j.1365-2249.2004.02592.x
dc.identifier.urihttp://hdl.handle.net/2436/29789
dc.description.abstractHuman endogenous retroviruses (HERVs) are a significant component of a wider family of retroelements that constitute part of the human genome. These viruses, perhaps representative of previous exogenous retroviral infection, have been integrated and passed through successive generations within the germ line. The retention of HERVs and isolated elements, such as long-terminal repeats, could have the potential to harm. In this review we describe HERVs within the context of the family of known transposable elements and survey these viruses in terms of superantigens and molecular mimics. It is entirely possible that these mechanisms provide the potential for undesired immune responses.
dc.language.isoen
dc.publisherWiley InterScience
dc.relation.urlhttp://www3.interscience.wiley.com/journal/118749005/abstract
dc.subjectAutoimmunity
dc.subjectHuman Endogenous Retroviruses
dc.subjectMolecular Mimicry
dc.subjectTransposable Elements
dc.subject.meshDNA Transposable Elements
dc.subject.meshDNA, Viral
dc.subject.meshEndogenous Retroviruses
dc.subject.meshEvolution, Molecular
dc.subject.meshGenome, Human
dc.subject.meshHumans
dc.subject.meshLong Interspersed Nucleotide Elements
dc.subject.meshRetroviridae Infections
dc.subject.meshShort Interspersed Nucleotide Elements
dc.subject.meshSuperantigens
dc.subject.meshTerminal Repeat Sequences
dc.subject.meshVirus Integration
dc.titleHuman endogenous retroviruses: transposable elements with potential?
dc.typeArticle
dc.identifier.journalClinical and Experimental Immunology
html.description.abstractHuman endogenous retroviruses (HERVs) are a significant component of a wider family of retroelements that constitute part of the human genome. These viruses, perhaps representative of previous exogenous retroviral infection, have been integrated and passed through successive generations within the germ line. The retention of HERVs and isolated elements, such as long-terminal repeats, could have the potential to harm. In this review we describe HERVs within the context of the family of known transposable elements and survey these viruses in terms of superantigens and molecular mimics. It is entirely possible that these mechanisms provide the potential for undesired immune responses.


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