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    Human endogenous retroviruses: transposable elements with potential?

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    Authors
    Nelson, Paul N.
    Hooley, Paul
    Roden, Denise A.
    Ejtehadi, H. Davari
    Rylance, Paul
    Warren, Phil
    Martin, Jan H.
    Murray, Paul G.
    Issue Date
    2004
    
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    Abstract
    Human endogenous retroviruses (HERVs) are a significant component of a wider family of retroelements that constitute part of the human genome. These viruses, perhaps representative of previous exogenous retroviral infection, have been integrated and passed through successive generations within the germ line. The retention of HERVs and isolated elements, such as long-terminal repeats, could have the potential to harm. In this review we describe HERVs within the context of the family of known transposable elements and survey these viruses in terms of superantigens and molecular mimics. It is entirely possible that these mechanisms provide the potential for undesired immune responses.
    Citation
    Clinical and Experimental Immunology, 138(1): 1-9
    Publisher
    Wiley InterScience
    Journal
    Clinical and Experimental Immunology
    URI
    http://hdl.handle.net/2436/29789
    DOI
    10.1111/j.1365-2249.2004.02592.x
    PubMed ID
    15373898
    Additional Links
    http://www3.interscience.wiley.com/journal/118749005/abstract
    Type
    Journal article
    Language
    en
    ISSN
    0009-9104
    ae974a485f413a2113503eed53cd6c53
    10.1111/j.1365-2249.2004.02592.x
    Scopus Count
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    Research Institute in Healthcare Science

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