Human endogenous retroviruses: transposable elements with potential?
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Authors
Nelson, Paul N.Hooley, Paul
Roden, Denise A.
Ejtehadi, H. Davari
Rylance, Paul
Warren, Phil
Martin, Jan H.
Murray, Paul G.
Issue Date
2004
Metadata
Show full item recordAbstract
Human endogenous retroviruses (HERVs) are a significant component of a wider family of retroelements that constitute part of the human genome. These viruses, perhaps representative of previous exogenous retroviral infection, have been integrated and passed through successive generations within the germ line. The retention of HERVs and isolated elements, such as long-terminal repeats, could have the potential to harm. In this review we describe HERVs within the context of the family of known transposable elements and survey these viruses in terms of superantigens and molecular mimics. It is entirely possible that these mechanisms provide the potential for undesired immune responses.Citation
Clinical and Experimental Immunology, 138(1): 1-9Publisher
Wiley InterScienceJournal
Clinical and Experimental ImmunologyPubMed ID
15373898Additional Links
http://www3.interscience.wiley.com/journal/118749005/abstractType
Journal articleLanguage
enISSN
0009-9104ae974a485f413a2113503eed53cd6c53
10.1111/j.1365-2249.2004.02592.x
Scopus Count
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