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    Phytoestrogens: perpetrators or protectors?

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    Authors
    Martin, Jan H.
    Crotty, Stephen
    Nelson, Paul N.
    Issue Date
    2007
    
    Metadata
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    Abstract
    Phytoestrogens are estrogen-like substances produced by plants that account for some of the constituents present in vegetation that may be responsible for the health benefits of a diet rich in fruit and vegetables. Phytoestrogens have a plethora of different actions that they are capable of exerting on cellular metabolism. This review will focus on some of the major non-estrogen receptor-mediated cellular effects used by phytoestrogens and will draw attention to the fact that while they may have a number of beneficial effects, particularly in offering a protective effect against some hormone-dependent cancers, such as breast and prostate cancer, they may also have possible unfavorable effects by interfering with the functioning of normal cellular activities such as receptor-mediated signal transduction and DNA replication, as well as being genotoxic, mutagenic and promoting the proliferation of some cancer cells.
    Citation
    Future Oncology, 3(3): 307-318
    Publisher
    Future Medicine Ltd
    Journal
    Future Oncology
    URI
    http://hdl.handle.net/2436/29765
    DOI
    10.2217/14796694.3.3.307
    PubMed ID
    17547526
    Additional Links
    http://www.futuremedicine.com/doi/abs/10.2217/14796694.3.3.307
    Type
    Journal article
    Language
    en
    ISSN
    1479-6694
    ae974a485f413a2113503eed53cd6c53
    10.2217/14796694.3.3.307
    Scopus Count
    Collections
    Research Institute in Healthcare Science

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