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dc.contributor.authorNelson, Paul N.
dc.contributor.authorCarnegie, P.R.
dc.contributor.authorMartin, Jan H.
dc.contributor.authorEjtehadi, H. Davari
dc.contributor.authorHooley, Paul
dc.contributor.authorRoden, Denise A.
dc.contributor.authorRowland-Jones, S.
dc.contributor.authorWarren, Phil
dc.contributor.authorAstley, S.J.
dc.contributor.authorMurray, Paul G.
dc.date.accessioned2008-06-05T13:12:50Z
dc.date.available2008-06-05T13:12:50Z
dc.date.issued2003
dc.identifier.citationJournal of Clinical Pathology: Molecular Pathology, 56 (1): 11-18
dc.identifier.issn1366-8714
dc.identifier.pmid12560456
dc.identifier.urihttp://hdl.handle.net/2436/29583
dc.description.abstractHuman endogenous retroviruses (HERVs) are a family of viruses within our genome with similarities to present day exogenous retroviruses. HERVs have been inherited by successive generations and it is possible that some have conferred biological benefits. However, several HERVs have been implicated in certain cancers and autoimmune diseases. This article demystifies these retroviruses by providing an insight into HERVs, their means of classification, and a synopsis of HERVs implicated in cancer and autoimmunity. Furthermore, the biological roles of HERVs are explored.
dc.language.isoen
dc.publisherBMJ Publishing
dc.relation.urlhttp://mp.bmj.com/cgi/content/full/56/1/11
dc.subjectHuman Endogenous Retroviruses
dc.subjectCancer
dc.subjectAutoimmunity
dc.subject.meshAntibodies, Viral
dc.subject.meshAntigens, Viral
dc.subject.meshAutoimmune Diseases
dc.subject.meshCodon, Nonsense
dc.subject.meshDNA
dc.subject.meshDNA Transposable Elements
dc.subject.meshDrug Resistance, Viral
dc.subject.meshEndogenous Retroviruses
dc.subject.meshGenes, Viral
dc.subject.meshGenome, Human
dc.subject.meshHumans
dc.subject.meshNeoplasms
dc.subject.meshPeptides
dc.subject.meshRNA, Messenger
dc.subject.meshTerminal Repeat Sequences
dc.subject.meshTranscription, Genetic
dc.titleDemystified. Human endogenous retroviruses.
dc.typeArticle
dc.identifier.journalJournal of Clinical Pathology: Molecular Pathology
html.description.abstractHuman endogenous retroviruses (HERVs) are a family of viruses within our genome with similarities to present day exogenous retroviruses. HERVs have been inherited by successive generations and it is possible that some have conferred biological benefits. However, several HERVs have been implicated in certain cancers and autoimmune diseases. This article demystifies these retroviruses by providing an insight into HERVs, their means of classification, and a synopsis of HERVs implicated in cancer and autoimmunity. Furthermore, the biological roles of HERVs are explored.


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