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    Vitamin E correlates inversely with non-transferrin-bound iron in sickle cell disease.

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    Authors
    Marwah, S.S.
    Wheelwright, D.
    Blann, A.D.
    Rea, C.
    Beresford, R.
    Phillips, Jonathan D.
    Wright, J.
    Bareford, D.
    Issue Date
    2001
    
    Metadata
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    Abstract
    Decreased serum vitamin E levels are found in homozygous sickle cell disease (SCD). Excessive transfusions may lead high non-transferrin-bound iron (NTBI). Hypothesizing a relationship between the two, vitamin E (measured using high performance liquid chromatography) was significantly lower in 30 SCD patients than in 30 age-/sex-matched controls (P < 0.001), but NTBI (bleomycin assay) was higher (P < 0.001). Vitamin E was lower in 10 transfused patients than in 20 non-transfused patients (P < 0.001) with a significant inverse correlation between the NTBI and vitamin E (r = -0.58, P < 0.001). NTBI associated with iron overload in SCD may increase the potential for oxidative damage and low vitamin E activity may compound this effect.
    Citation
    British Journal of Haematology, 114(4): 917-919
    Publisher
    Wiley InterScience
    Journal
    British Journal of Haematology
    URI
    http://hdl.handle.net/2436/29475
    DOI
    10.1046/j.1365-2141.2001.03018.x
    PubMed ID
    11564086
    Additional Links
    http://www.ingentaconnect.com/content/bsc/bjh/2001/00000114/00000004/art00028http://www3.interscience.wiley.com/journal/121374046/abstract
    Type
    Journal article
    Language
    en
    ISSN
    0007-1048
    ae974a485f413a2113503eed53cd6c53
    10.1046/j.1365-2141.2001.03018.x
    Scopus Count
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    Research Institute in Healthcare Science

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