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    Increased non-transferrin bound iron in plasma-depleted SAG-M red blood cell units.

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    Authors
    Marwah, S.S.
    Blann, A.D.
    Harrison, P.
    Lumley, M.A.
    Wright, J.
    McDowell, J.
    Phillips, Jonathan D.
    Rea, C.
    Bareford, D.
    Issue Date
    2002
    
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    Abstract
    BACKGROUND AND OBJECTIVES: Non-transferrin bound iron (NTBI) is associated with increased morbidity in a number of transfusion-dependent disease states such as the severe haemoglobinopathies. We hypothesized that this may be related to excess NTBI present in plasma-depleted red blood cell units that are free of clear haemolysis. MATERIALS AND METHODS: The level of NTBI was determined using the bleomycin assay in samples from 20 stored plasma-depleted red cell units, at approximate 5-day intervals up to day 33 after donation. Forty units of fresh-frozen plasma (FFP) and 40 units of platelet concentrates were used as negative controls, and samples from 12 units of FFP were also serially assessed. RESULTS: Median [interquartile range (IQR)] NTBI was 0 microm (0-0.35) in samples taken from units 3-10 days after donation. Thereafter, the levels of NTBI increased, becoming significant (median 3.05; IQR: 0.05-6.7 microm) 17-22 days after donation. After 30 days, NTBI was detectable in all red cell units. NTBI was undetectable in platelet concentrates and FFP. CONCLUSIONS: Increased levels of NTBI become detectable 17-22 days after donation and increase further with storage time. This excess NTBI may promote bacterial infection in iron-loaded individuals.
    Citation
    Vox Sanguinis, 82(3): 122-126
    Publisher
    Wiley InterScience
    Journal
    Vox Sanguinis
    URI
    http://hdl.handle.net/2436/29473
    DOI
    10.1046/j.1423-0410.2002.00153.x
    PubMed ID
    11952985
    Additional Links
    http://www.ingentaconnect.com/content/bsc/vox/2002/00000082/00000003/art00003
    Type
    Journal article
    Language
    en
    ISSN
    0042-9007
    ae974a485f413a2113503eed53cd6c53
    10.1046/j.1423-0410.2002.00153.x
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