• Admin Login
    View Item 
    •   Home
    • Research Institute in Healthcare Science
    • Research Institute in Healthcare Science
    • View Item
    •   Home
    • Research Institute in Healthcare Science
    • Research Institute in Healthcare Science
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of WIRECommunitiesTitleAuthorsIssue DateSubmit DateSubjectsTypesJournalDepartmentPublisherThis CollectionTitleAuthorsIssue DateSubmit DateSubjectsTypesJournalDepartmentPublisher

    Administrators

    Admin Login

    Local Links

    AboutThe University LibraryOpen Access Publications PolicyDeposit LicenceCOREWIRE Copyright and Reuse Information

    Statistics

    Display statistics

    A pilot study to determine the effectiveness of garlic oil capsules in the treatment of dyspeptic patients with Helicobacter pylori.

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Average rating
     
       votes
    Cast your vote
    You can rate an item by clicking the amount of stars they wish to award to this item. When enough users have cast their vote on this item, the average rating will also be shown.
    Star rating
     
    Your vote was cast
    Thank you for your feedback
    Authors
    McNulty, Cliodna A. M.
    Wilson, Melanie P.
    Havinga, Wouter
    Johnston, Belinda
    O'Gara, Elizabeth A.
    Maslin, David J.
    Issue Date
    2001
    
    Metadata
    Show full item record
    Abstract
    BACKGROUND: Resistance of Helicobacter pylori to clarithromycin and metronidazole is now found worldwide. Steam-distilled garlic oil has in vitro activity against H. pylori and may be a useful alternative treatment strategy. MATERIALS AND METHODS: In this pilot study dyspeptic patients with positive serology for H. pylori confirmed by 13C urea breath test (UBT), at 0 and 2 weeks, were enrolled. Treatment consisted of one 4 mg garlic oil capsule with a meal four times per day for 14 days. H. pylori eradication was defined as a negative UBT at both follow-up appointments. Suppression was defined as a 50% fall in 13C excess between baseline and follow-up 1. RESULTS: Five patients completed the study. There was no evidence of either eradication or suppression of H. pylori or symptom improvement whilst taking garlic oil. CONCLUSION: These negative results show that, within the gastric milieu, garlic oil at this dose does not inhibit H. pylori. A higher dose administered for a longer time-period may be effective. Antibiotics are usually combined with a proton-pump inhibitor or bismuth salt, as the only antibiotic with any in vivo activity against H. pylori in monotherapy is clarithromycin. A proton pump inhibitor raises gastric pH and, by increasing bacterial division, may increase the in vivo activity of garlic oil. This may be worth pursuing in a future trial.
    Citation
    Helicobacter, 6(3): 249-253
    Publisher
    Wiley InterScience
    Journal
    Helicobacter
    URI
    http://hdl.handle.net/2436/29464
    DOI
    10.1046/j.1523-5378.2001.00036.x
    PubMed ID
    11683929
    Additional Links
    http://www3.interscience.wiley.com/journal/120846013/abstract
    Type
    Journal article
    Language
    en
    ISSN
    1083-4389
    ae974a485f413a2113503eed53cd6c53
    10.1046/j.1523-5378.2001.00036.x
    Scopus Count
    Collections
    Research Institute in Healthcare Science

    entitlement

    Related articles

    • Comparison of sequential and standard triple-drug regimen for Helicobacter pylori eradication: a 14-day, open-label, randomized, prospective, parallel-arm study in adult patients with nonulcer dyspepsia.
    • Authors: Uygun A, Kadayifci A, Yesilova Z, Safali M, Ilgan S, Karaeren N
    • Issue date: 2008 Mar
    • Ranitidine bismuth citrate with clarithromycin alone or with metronidazole for the eradication of Helicobacter pylori.
    • Authors: Bardhan KD, Morton D, Perry MJ, Sanders DS, Morris P, Rowland A, Thompson M, Mitchell TR, Roberts PM
    • Issue date: 2001 Aug
    • Garlic oil and Helicobacter pylori infection.
    • Authors: Aydin A, Ersöz G, Tekesin O, Akçiçek E, Tuncyürek M
    • Issue date: 2000 Feb
    • Eradication Rate of <i>Helicobacter pylori</i> on the US-Mexico Border Using the Urea Breath Test.
    • Authors: Liu RP, Romero R, Sarosiek J, Dodoo C, Dwivedi AK, Zuckerman MJ
    • Issue date: 2018 Jan
    • One-week ranitidine bismuth citrate in combinations with metronidazole, amoxycillin and clarithromycin in the treatment of Helicobacter pylori infection: the RBC-MACH study.
    • Authors: Sung JJ, Chan FK, Wu JC, Leung WK, Suen R, Ling TK, Lee YT, Cheng AF, Chung SC
    • Issue date: 1999 Aug

    DSpace software (copyright © 2002 - 2021)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.