Role of sexual behavior in the acquisition of asymptomatic Epstein-Barr virus infection: a longitudinal study.
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
Nelson, Paul N.
Young, Lawrence S.
Murray, Paul G.
MetadataShow full item record
AbstractBACKGROUND: The natural history of Epstein-Barr virus (EBV) infection is poorly defined. We report the prevalence and subsequent incidence of EBV infection in a cohort of sexually active young women and explore the social and sexual determinants of incident infections. METHODS: The study population was drawn from a cohort of young women, who were recruited for a longitudinal study of risk factors for early cervical neoplasia. A case-control analysis, nested within the cohort of 45 women for whom the first EBV sample tested was EBV-negative and who had further follow-up, was undertaken. EBV serostatus was determined in serum with a synthetic peptide-based enzyme-linked immunosorbent assay; EBV DNA was measured in cervical smears with the use of quantitative polymerase chain reaction. RESULTS: Of 1023 women 15-19 years of age included in this analysis, 978 (95.6%) tested positive for antibodies to EBV in their first serum sample. Of 45 women who tested negative, 22 subsequently acquired an asymptomatic EBV infection; the median time to seroconversion was 25 months (range, 1-60 months), and the median age at seroconversion was 18 years (range, 16-21 years). The risk of seroconversion increased with increasing number of sexual partners [compared with 1 partner, odds ratio (OR) was 1.28 for 2 partners and 2.23 for 3 or more; chiTREND 5.02; df 1; P < 0.05] and was greatest when a new sexual partner had been acquired in the 2 years before seroconversion (OR 4.78; chi 4.62; df 1; P < 0.05). EBV DNA was detected in 9 of 14 women who seroconverted and who also provided cervical samples. CONCLUSIONS: In susceptible young women, the acquisition of EBV infection is associated with their sexual behavior.
CitationPediatric Infectious Diseases Journal, 24 (6): 498-502
PublisherLippincott Williams & Wilkins
JournalPediatric Infectious Diseases Journal
- Epstein-Barr virus DNA in the uterine cervix of teenage girls.
- Authors: Andersson-Ellström A, Bergström T, Svennerholm B, Milsom I
- Issue date: 1997 Sep
- A study of risk factors for acquisition of Epstein-Barr virus and its subtypes.
- Authors: Higgins CD, Swerdlow AJ, Macsween KF, Harrison N, Williams H, McAulay K, Thomas R, Reid S, Conacher M, Britton K, Crawford DH
- Issue date: 2007 Feb 15
- Detection of Epstein-Barr virus, but not human herpesvirus 8, DNA in cervical secretions from Swedish women by real-time polymerase chain reaction.
- Authors: Enbom M, Strand A, Falk KI, Linde A
- Issue date: 2001 May
- Sexual history and Epstein-Barr virus infection.
- Authors: Crawford DH, Swerdlow AJ, Higgins C, McAulay K, Harrison N, Williams H, Britton K, Macsween KF
- Issue date: 2002 Sep 15
- Lifetime number of partners as the only independent risk factor for human papillomavirus infection: a population-based study.
- Authors: Karlsson R, Jonsson M, Edlund K, Evander M, Gustavsson A, Bodén E, Rylander E, Wadell G
- Issue date: 1995 Mar-Apr