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    The effect of simulated gastric environments on the anti-Helicobacter activity of garlic oil.

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    Authors
    O'Gara, Elizabeth A.
    Maslin, David J.
    Nevill, Alan M.
    Hill, David J.
    Issue Date
    2008
    
    Metadata
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    Abstract
    AIMS: To investigate the effects of simulated gastric conditions upon the anti-Helicobacter pylori effects of garlic oil (GO). METHODS AND RESULTS: Time course viability experiments assessed the anti-H. pylori activity of GO (16 and 32 microg ml(-1)) in simulated gastric environments. Rapid anti-H. pylori action of GO was observed in artificial gastric juice. Mucus (1-5%) was strongly protective of H. pylori both alone and in the presence of GO, but its protective effect was antagonized by GO. Peptone (5-15 g l(-1)) caused a dose-dependent reduction in the anti-H. pylori activity of GO. Rapeseed oil (5.7-17 g l(-1)) greatly diminished the anti-H. pylori activity of GO. Dextrin (44 and 133 g l(-1)) exhibited direct anti-H. pylori effects and added to those of GO. Simulated meal mixtures decreased but did not eliminate the anti-H. pylori activity of 32 mug ml(-1) GO. CONCLUSIONS: The anti-H. pylori activity of GO was noticeably affected by food materials and mucin. However, substantial activity remained under simulated gastric conditions. Further investigation of the therapeutic potential of GO against H. pylori is therefore warranted. SIGNIFICANCE AND IMPACT OF THE STUDY: Garlic oil may be useful as an alternative treatment against H. pylori, a major cause of gastrointestinal infections in humans.
    Citation
    Journal of Applied Microbiology, 104(5): 1324-1331
    Publisher
    Blackwell Synergy
    Journal
    Journal of Applied Microbiology
    URI
    http://hdl.handle.net/2436/29450
    DOI
    10.1111/j.1365-2672.2007.03637.x
    PubMed ID
    18028365
    Additional Links
    http://www.ingentaconnect.com/content/bsc/jam/2008/00000104/00000005/art00011?token=004f162774df85437a63736a425547355d23663444452a3e6f644a467b4d616d3f4e4b34774759d
    Type
    Journal article
    Language
    en
    ISSN
    1365-2672
    ae974a485f413a2113503eed53cd6c53
    10.1111/j.1365-2672.2007.03637.x
    Scopus Count
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    Faculty of Education, Health and Wellbeing

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