South Asian ethnicity and material deprivation increase the risk of Epstein-Barr virus infection in childhood Hodgkin's disease.
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
Nelson, Paul N.
Young, Lawrence S.
Murray, Paul G.
MetadataShow full item record
AbstractIn order to further define the factors associated with the observed variations in the Epstein-Barr virus-positive rate in childhood Hodgkin's disease, we have studied the effect of material deprivation (measured by the Townsend score) and ethnic origin on the frequency of Epstein-Barr virus-positivity in 55 cases of childhood Hodgkin's disease, diagnosed between 1981 and 1999, from a multi-ethnic region of the United Kingdom. Epstein-Barr virus status was determined by immunohistochemistry for the Epstein-Barr virus-encoded latent membrane protein-1. 62% of cases were Epstein-Barr virus-positive. Ethnic group was the strongest predictor of Epstein-Barr virus-positivity, with South Asians having a more than 20-fold risk of being Epstein-Barr virus-positive compared with non-South Asians. An increased risk was still present after adjusting for deprivation. Townsend scores were significantly higher (indicating more deprivation) in the Epstein-Barr virus-positive group, particularly in males. The relative risk of Epstein-Barr virus-positivity showed a gradient with increasing Townsend score; the risk being 7-times higher in the most deprived quartile compared with the least deprived group. Although the association between Townsend score and Epstein-Barr virus-positivity was reduced after adjusting for ethnic group, the risk of Epstein-Barr virus-positivity was still 3-times higher in the most deprived compared with the least deprived quartile. In addition, cases having 2 or more siblings were 5-times as likely to be Epstein-Barr virus-positive as those from smaller families. These results provide the first evidence of a strong association between Epstein-Barr virus-positive Hodgkin's disease and South Asian children from the United Kingdom. In addition, deprivation may increase the likelihood of Epstein-Barr virus-positive disease independently of ethnicity.
CitationBritish Journal of Cancer, 85 (3): 350-6
PublisherNature Publishing Group
JournalBritish Journal of Cancer
- Longer failure-free survival interval of Epstein-Barr virus-associated classical Hodgkin's lymphoma: a single-institution study.
- Authors: Krugmann J, Tzankov A, Gschwendtner A, Fischhofer M, Greil R, Fend F, Dirnhofer S
- Issue date: 2003 Jun
- [Association of Hodgkin lymphoma with Epstein-Barr virus in Hungary].
- Authors: Keresztes K, Bessenyei B, Szöllosi Z, Beck Z, Miltényi Z, Nemes Z, Oláh E, Illés A
- Issue date: 2005 Jul 24
- [Epstein-Barr virus in Hodgkin's disease: the example of central Tunisia].
- Authors: Korbi S, Trimeche M, Sriha B, Yacoubi MT, Hmissa S, Mokni M, Delvenne P, Boniver J, Rammeh S
- Issue date: 2002 Apr
- Epstein-Barr virus (EBV) and Hodgkin's disease in children: incidence of EBV latent membrane protein in malignant cells.
- Authors: Weinreb M, Day PJ, Murray PG, Raafat F, Crocker J, Parkes SE, Coad NA, Jones JT, Mann JR
- Issue date: 1992 Dec
- [Elevated Epstein-Barr virus antibodies in patients with Hodgkin's disease].
- Authors: Kuljić-Kapulica N
- Issue date: 1998 Mar-Apr