• Admin Login
    View Item 
    •   Home
    • Faculty of Education, Health and Wellbeing
    • Faculty of Education, Health and Wellbeing
    • View Item
    •   Home
    • Faculty of Education, Health and Wellbeing
    • Faculty of Education, Health and Wellbeing
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of WIRECommunitiesTitleAuthorsIssue DateSubmit DateSubjectsTypesJournalDepartmentPublisherThis CollectionTitleAuthorsIssue DateSubmit DateSubjectsTypesJournalDepartmentPublisher

    Administrators

    Admin Login

    Local Links

    AboutThe University LibraryOpen Access Publications PolicyDeposit LicenceCOREWIRE Copyright and Reuse Information

    Statistics

    Display statistics

    High diversity of non-human leukocyte antigens in transplant-associated coronary artery disease.

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Authors
    Bates, Ruth L.
    Frampton, Geoffrey
    Rose, Marlene L.
    Murphy, John J.
    Issue Date
    2003
    
    Metadata
    Show full item record
    Abstract
    BACKGROUND: Antibodies to endothelial derived non-human leukocyte antigens (HLA) have been associated with transplant (Tx)-associated coronary artery disease (CAD) after cardiac transplantation; however, few have been identified. The aim of this study was to screen a human coronary artery endothelial cell cDNA library with patient sera to establish the diversity and nature of the target antigens. METHODS: A human coronary artery endothelial cell cDNA library was screened with sera from seven long-term cardiac transplant patients with angiographically diagnosed TxCAD and sera from five healthy volunteers. RESULTS: Of the seven patients' sera, five showed reactivity, as did sera from two of the five normal subjects. Eighteen positive cDNA clones were isolated by TxCAD sera; DNA sequence analysis and DNA database searching identified all but one clone; 16 were nuclear or cytoplasmic proteins and 1 of them was the cell surface protein neuropilin 2. Five clones were targeted by normal sera. A different spectrum of reactive clones was identified by the sera of each patient where reactive clones were evident. CONCLUSIONS: A high diversity of non-HLA antigens, probably autoantigens, are involved in the pathogenesis of TxCAD.
    Citation
    Transplantation, 75(8): 1347-1350
    Publisher
    Lippincott Williams & Wilkins
    Journal
    Transplantation
    URI
    http://hdl.handle.net/2436/29437
    DOI
    10.1097/01.TP.0000061790.08550.EC
    PubMed ID
    12717228
    Additional Links
    http://www.transplantjournal.com/pt/re/transplantation/abstract.00007890-200304270-00057.htm
    Type
    Journal article
    Language
    en
    ISSN
    0041-1337
    ae974a485f413a2113503eed53cd6c53
    10.1097/01.TP.0000061790.08550.EC
    Scopus Count
    Collections
    Faculty of Education, Health and Wellbeing

    entitlement

    Related articles

    • Molecular cloning and expression of 56-58 KD antigen associated with transplant coronary artery disease.
    • Authors: Ationu A, Collins A
    • Issue date: 1997 Jul 30
    • Identification of endothelial antigens relevant to transplant coronary artery disease from a human endothelial cell cDNA expression library.
    • Authors: Ationu A
    • Issue date: 1998 Jun
    • Antiendothelial antibodies after heart transplantation: the accelerating factor in transplant-associated coronary artery disease?
    • Authors: Crisp SJ, Dunn MJ, Rose ML, Barbir M, Yacoub MH
    • Issue date: 1994 Jan-Feb
    • Immunoglobulin M-to-immunoglobulin G anti-human leukocyte antigen class II antibody switching in cardiac transplant recipients is associated with an increased risk of cellular rejection and coronary artery disease.
    • Authors: Lietz K, John R, Burke E, Schuster M, Rogers TB, Suciu-Foca N, Mancini D, Itescu S
    • Issue date: 2005 Oct 18
    • Antivimentin antibodies are an independent predictor of transplant-associated coronary artery disease after cardiac transplantation.
    • Authors: Jurcevic S, Ainsworth ME, Pomerance A, Smith JD, Robinson DR, Dunn MJ, Yacoub MH, Rose ML
    • Issue date: 2001 Apr 15
    DSpace software (copyright © 2002 - 2023)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.