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    A polyphosphate kinase 1 (ppk1) mutant of Pseudomonas aeruginosa exhibits multiple ultrastructural and functional defects.

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    Authors
    Fraley, Cresson D.
    Rashid, M. Harunur
    Lee, Sam S. K.
    Gottschalk, Rebecca
    Harrison, Janine
    Wood, Pauline J.
    Brown, Michael R. W.
    Kornberg, Arthur
    Issue Date
    2007
    
    Metadata
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    Abstract
    Pseudomonas aeruginosa, of medical, environmental, and industrial importance, depends on inorganic polyphosphate (poly P) for a wide range of functions, especially survival. Mutants of PAO1 lacking poly P kinase 1, PPK1, the enzyme responsible for most poly P synthesis in Escherichia coli and other bacteria, are defective in motility, quorum sensing, biofilm formation, and virulence. We describe here multiple defects in the ppk1 mutant PAOM5, including a striking compaction of the nucleoid, distortion of the cell envelope, lack of planktonic motility and exopolymer production, and susceptibility to the beta-lactam antibiotic carbenicillin as well as desiccation. We propose that P. aeruginosa with reduced poly P levels undergoes ultrastructural changes that contribute to profound deficiencies in cellular functions.
    Citation
    Proceedings of the National Academy of Sciences of the United States of America, 104 (9): 3526-3531
    Publisher
    National Academy of Sciences
    Journal
    Proceedings of the National Academy of Sciences of the United States of America
    URI
    http://hdl.handle.net/2436/27672
    DOI
    10.1073/pnas.0609733104
    PubMed ID
    17360677
    Additional Links
    http://www.pnas.org/cgi/content/full/104/9/3526
    Type
    Journal article
    Language
    en
    ISSN
    0027-8424
    ae974a485f413a2113503eed53cd6c53
    10.1073/pnas.0609733104
    Scopus Count
    Collections
    Research Institute in Healthcare Science

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