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dc.contributor.authorDay, Stephen H.
dc.contributor.authorGohlke, Peter
dc.contributor.authorDhamrait, Sukhbir S.
dc.contributor.authorWilliams, Alun G.
dc.date.accessioned2008-04-10T10:45:49Z
dc.date.available2008-04-10T10:45:49Z
dc.date.issued2007
dc.identifier.citationEuropean Journal of Applied Physiology, 99 (1): 11-18
dc.identifier.issn1439-6319
dc.identifier.pmid17006710
dc.identifier.doi10.1007/s00421-006-0309-3
dc.identifier.urihttp://hdl.handle.net/2436/22861
dc.description.abstractThe insertion (I) variant of the angiotensin-1 converting enzyme (ACE) I/D genetic polymorphism is associated with lower circulating and tissue ACE activity. Some studies have also suggested associations of ACE I/D genotype with endurance phenotypes. This study assessed the relationships between circulating ACE activity, ACE I/D genotype, mechanical efficiency and the maximal rate of oxygen uptake in sedentary individuals. Sixty-two untrained women were tested for mechanical efficiency during submaximal cycle ergometry (delta and gross efficiencies during exercise between 40 and 80 W) and the maximal rate of oxygen uptake during incremental treadmill running. Respiratory variables were measured using indirect calorimetry. Venous blood was obtained for direct assay of circulating ACE activity, allowing for the assessment of correlations between two continuous variables, rather than a categorical analysis of endurance phenotype by genotype alone. ACE I/D genotype was also determined, and was strongly associated with circulating ACE activity (P < 0.0005). Neither circulating ACE activity (27.4 +/- 8.4 nM His-Leu-ml(-1)) nor ACE genotype showed a statistically significant association with any of the endurance phenotypes measured. The weak correlations observed included r = -0.122 (P = 0.229) for the relationship between delta efficiency (23.9 +/- 2.5%) and circulating ACE activity and r = 0.134 (P > 0.6) for the relationship between maximal aerobic power (149.1 +/- 22.9 ml kg(-2/3) min(-1)) and circulating ACE activity. The data do not support a role for systemic ACE activity in the regulation of endurance performance in sedentary individuals, extending this observation to a large female cohort.
dc.language.isoen
dc.publisherSpringer
dc.relation.urlhttp://www.springerlink.com/content/fn831636n85684l5/
dc.subjectAngiotensin-1 converting enzyme
dc.subjectAerobic capacity
dc.subjectEndurance
dc.subjectGenetics
dc.subject.meshAdult
dc.subject.meshCohort Studies
dc.subject.meshExercise
dc.subject.meshExercise Test
dc.subject.meshFemale
dc.subject.meshGenotype
dc.subject.meshHumans
dc.subject.meshMuscle, Skeletal
dc.subject.meshOxygen Consumption
dc.subject.meshPeptidyl-Dipeptidase A
dc.subject.meshPhenotype
dc.subject.meshPhysical Endurance
dc.subject.meshPhysical Fitness
dc.subject.meshPolymorphism, Genetic
dc.titleNo correlation between circulating ACE activity and VO2max or mechanical efficiency in women.
dc.typeJournal article
dc.identifier.journalEuropean Journal of Applied Physiology
html.description.abstractThe insertion (I) variant of the angiotensin-1 converting enzyme (ACE) I/D genetic polymorphism is associated with lower circulating and tissue ACE activity. Some studies have also suggested associations of ACE I/D genotype with endurance phenotypes. This study assessed the relationships between circulating ACE activity, ACE I/D genotype, mechanical efficiency and the maximal rate of oxygen uptake in sedentary individuals. Sixty-two untrained women were tested for mechanical efficiency during submaximal cycle ergometry (delta and gross efficiencies during exercise between 40 and 80 W) and the maximal rate of oxygen uptake during incremental treadmill running. Respiratory variables were measured using indirect calorimetry. Venous blood was obtained for direct assay of circulating ACE activity, allowing for the assessment of correlations between two continuous variables, rather than a categorical analysis of endurance phenotype by genotype alone. ACE I/D genotype was also determined, and was strongly associated with circulating ACE activity (P < 0.0005). Neither circulating ACE activity (27.4 +/- 8.4 nM His-Leu-ml(-1)) nor ACE genotype showed a statistically significant association with any of the endurance phenotypes measured. The weak correlations observed included r = -0.122 (P = 0.229) for the relationship between delta efficiency (23.9 +/- 2.5%) and circulating ACE activity and r = 0.134 (P > 0.6) for the relationship between maximal aerobic power (149.1 +/- 22.9 ml kg(-2/3) min(-1)) and circulating ACE activity. The data do not support a role for systemic ACE activity in the regulation of endurance performance in sedentary individuals, extending this observation to a large female cohort.


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