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    No correlation between circulating ACE activity and VO2max or mechanical efficiency in women.

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    Authors
    Day, Stephen H.
    Gohlke, Peter
    Dhamrait, Sukhbir S.
    Williams, Alun G.
    Issue Date
    2007
    
    Metadata
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    Abstract
    The insertion (I) variant of the angiotensin-1 converting enzyme (ACE) I/D genetic polymorphism is associated with lower circulating and tissue ACE activity. Some studies have also suggested associations of ACE I/D genotype with endurance phenotypes. This study assessed the relationships between circulating ACE activity, ACE I/D genotype, mechanical efficiency and the maximal rate of oxygen uptake in sedentary individuals. Sixty-two untrained women were tested for mechanical efficiency during submaximal cycle ergometry (delta and gross efficiencies during exercise between 40 and 80 W) and the maximal rate of oxygen uptake during incremental treadmill running. Respiratory variables were measured using indirect calorimetry. Venous blood was obtained for direct assay of circulating ACE activity, allowing for the assessment of correlations between two continuous variables, rather than a categorical analysis of endurance phenotype by genotype alone. ACE I/D genotype was also determined, and was strongly associated with circulating ACE activity (P < 0.0005). Neither circulating ACE activity (27.4 +/- 8.4 nM His-Leu-ml(-1)) nor ACE genotype showed a statistically significant association with any of the endurance phenotypes measured. The weak correlations observed included r = -0.122 (P = 0.229) for the relationship between delta efficiency (23.9 +/- 2.5%) and circulating ACE activity and r = 0.134 (P > 0.6) for the relationship between maximal aerobic power (149.1 +/- 22.9 ml kg(-2/3) min(-1)) and circulating ACE activity. The data do not support a role for systemic ACE activity in the regulation of endurance performance in sedentary individuals, extending this observation to a large female cohort.
    Citation
    European Journal of Applied Physiology, 99 (1): 11-18
    Publisher
    Springer
    Journal
    European Journal of Applied Physiology
    URI
    http://hdl.handle.net/2436/22861
    DOI
    10.1007/s00421-006-0309-3
    PubMed ID
    17006710
    Additional Links
    http://www.springerlink.com/content/fn831636n85684l5/
    Type
    Journal article
    Language
    en
    ISSN
    1439-6319
    ae974a485f413a2113503eed53cd6c53
    10.1007/s00421-006-0309-3
    Scopus Count
    Collections
    Faculty of Education, Health and Wellbeing

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