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    Bradykinin receptor gene variant and human physical performance.

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    Authors
    Williams, Alun G.
    Dhamrait, Sukhbir S.
    Wootton, Peter T. E.
    Day, Stephen H.
    Hawe, Emma
    Payne, John R.
    Myerson, Saul G.
    World, Michael
    Budgett, Richard
    Humphries, Steve E.
    Montgomery, Hugh E.
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    Issue Date
    2004
    
    Metadata
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    Abstract
    Accumulating evidence suggests that athletic performance is strongly influenced by genetic variation. One such locus of influence is the gene for angiotensin-I converting enzyme (ACE), which exhibits a common variant [ACE insertion (I)/deletion (D)]. ACE can drive formation of vasoconstrictor ANG II but preferentially degrades vasodilator bradykinin. The ACE I allele is associated with higher kinin activity. A common gene variant in the kinin beta(2) receptor (B(2)R) exists: the -9 as opposed to +9 allele is associated with higher receptor mRNA expression. We tested whether this variant was associated with the efficiency of muscular contraction [delta efficiency (DE)] in 115 healthy men and women, or with running distance among 81 Olympic standard track athletes. We further sought evidence of biological interaction with ACE I/D genotype. DE was highly significantly associated with B(2)R genotype (23.84 +/- 2.41 vs. 24.25 +/- 2.81 vs. 26.05 +/- 2.26% for those of +9/+9 vs. +9/-9 vs. -9/-9 genotype; n = 25, 61, and 29, respectively; P = 0.0008 for ANOVA adjusted for sex). There was evidence for interaction with ACE I/D genotype, with individuals who were ACE II, with B(2)R -9/-9 having the highest DE at baseline. The ACE I/B(2)R -9 "high kinin receptor activity" haplotype was significantly associated with endurance (predominantly aerobic) event among elite athletes (P = 0.003). These data suggest that common genetic variation in the B(2)R is associated with efficiency of skeletal muscle contraction and with distance event of elite track athletes and that at least part of the associations of ACE and fitness phenotypes is through elevation of kinin activity.
    Citation
    Journal of Applied Physiology, 96(3): 938-942
    Publisher
    The American Physiological Society/HighWire Press
    Journal
    Journal of Applied Physiology
    URI
    http://hdl.handle.net/2436/22858
    DOI
    10.1152/japplphysiol.00865.2003
    PubMed ID
    14607851
    Additional Links
    https://www.physiology.org/doi/full/10.1152/japplphysiol.00865.2003
    Type
    Journal article
    Language
    en
    ISSN
    8750-7587
    ae974a485f413a2113503eed53cd6c53
    10.1152/japplphysiol.00865.2003
    Scopus Count
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    Faculty of Education, Health and Wellbeing

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