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    Exercise-induced oxidative stress in G6PD-deficient individuals.

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    Authors
    Nikolaidis, Michalis G.
    Jamurtas, Athanasios Z.
    Paschalis, Vassilis
    Kostaropoulos, Iason A.
    Kladi-Skandali, Athina
    Balamitsi, Vera
    Koutedakis, Yiannis
    Kouretas, Dimitris
    Issue Date
    2006
    
    Metadata
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    Abstract
    PURPOSE: This study was designed to investigate whether individuals with glucose-6-phosphate dehydrogenase (G6PD) deficiency can exercise without greater perturbations in their redox status compared with non-G6PD-deficient individuals. METHODS: Nine males with established G6PD deficiency and nine males with normal G6PD activity performed two exhaustive treadmill exercise protocols of different duration (the shorter one lasting 12 min and the longer one 50 min). Several hematological parameters, reduced glutathione (GSH), oxidized glutathione (GSSG), thiobarbituric acid reactive substances (TBARS), protein carbonyls, catalase, and total antioxidant capacity (TAC) were measured in the blood before and after each exercise bout. RESULTS: Both GSH and GSSG were significantly higher in the control group compared with the G6PD-deficient group at baseline (0.404 +/- 0.101 vs 0.195 +/- 0.049 mmol.L(-1) for GSH and 0.047 +/- 0.012 vs 0.012 +/- 0.006 mmol.L(-1) for GSSG; P < 0.05); as a result, their ratio was not significantly different between the two groups (P > 0.05). All other oxidative stress indices were not different between groups at rest (P > 0.05). Exercise of both durations affected significantly (P < 0.05) and similarly the levels of all oxidative stress indices either in the G6PD-deficient group or in the control group. Only the long exercise affected GSH status significantly (P < 0.05), whereas both short and long exercise increased the levels of TBARS, protein carbonyls, catalase activity, and TAC to a similar extent (P < 0.05). CONCLUSION: G6PD-deficient individuals are able to exercise until exhaustion without higher oxidative stress compared with non-G6PD-deficient individuals. Exercise duration is an important determinant of the magnitude of exercise-induced changes for GSH, GSSG, and GSH/GSSG, but not for TBARS, protein carbonyls, catalase activity, or TAC.
    Citation
    Medicine & Science in Sports & Exercise, 38(8): 1443-1450
    Publisher
    Lippincott Williams & Wilkins
    Journal
    Medicine & Science in Sports & Exercise
    URI
    http://hdl.handle.net/2436/22857
    DOI
    10.1249/01.mss.0000228938.24658.5f
    PubMed ID
    16888458
    Additional Links
    http://www.acsm-msse.org/pt/re/msse/abstract.00005768-200608000-00012.htm
    Type
    Journal article
    Language
    en
    ISSN
    0195-9131
    ae974a485f413a2113503eed53cd6c53
    10.1249/01.mss.0000228938.24658.5f
    Scopus Count
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