Redefining overweight and obesity in rheumatoid arthritis patients
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
Metsios, Giorgos S.
Nevill, Alan M.
Douglas, Karen M. J.
Jamurtas, Athanasios Z.
van Zanten, J.
Kitas, George D.
MetadataShow full item record
AbstractOBJECTIVES: To assess whether body mass index (BMI) and body fat (BF) differ between rheumatoid arthritis (RA) patients, patients with non-inflammatory arthritis (osteoarthritis, OA) and healthy individuals, and whether disease specific measures of adiposity are required to accurately reflect BF in these groups. METHODS: 641 individuals were assessed for BMI (kg/m(2)) and BF (bioelectrical impedance). Of them, 299 (174 RA, 43 OA and 82 healthy controls (HC)) formed the observation group and 342 (all RA) the validation group. RA disease characteristics were collected. RESULTS: ANOVA revealed significant differences between disease groups for BMI (p<0.05) and BF (p<0.001). ANCOVA showed that age accounted for the differences in BMI (F(1,294) = 5.10, p<0.05); age (F(1,293) = 22.43, p<0.001), sex (F(1,293) = 380.90, p<0.001) and disease (F(2, 293) = 18.7, p<0.001) accounted for the differences in BF. For a given BF, patients with RA exhibited BMI levels reduced by 1.83 kg/m(2) (p<0.001) compared to HC; there were no significant differences between OA and HC. A predictive model for BF was developed (R(2) = 0.769, p<0.001) and validated using limits of agreement Analysis against measured BF in the validation group (95%LIM(AG) = 6.17; CV = 8.94). CONCLUSIONS: In individuals with RA, BMI cut-off points should be reduced by 2 kg/m(2) (that is, to 23 kg/m(2) for overweight and 28 kg/m(2) for obesity). The equation developed can be used to accurately predict BF from BMI in RA patients. These findings may be important in the context of the cardiovascular comorbidity of RA.
CitationAnnals of the Rheumatic Diseases, 66 (10): 1316-21
JournalAnnals of the Rheumatic Diseases
- BMI does not accurately predict overweight in Asian Indians in northern India.
- Authors: Dudeja V, Misra A, Pandey RM, Devina G, Kumar G, Vikram NK
- Issue date: 2001 Jul
- Cigarette smoking associates with body weight and muscle mass of patients with rheumatoid arthritis: a cross-sectional, observational study.
- Authors: Stavropoulos-Kalinoglou A, Metsios GS, Panoulas VF, Douglas KM, Nevill AM, Jamurtas AZ, Kita M, Koutedakis Y, Kitas GD
- Issue date: 2008
- Sex differences in assessment of obesity in rheumatoid arthritis.
- Authors: Katz PP, Yazdany J, Trupin L, Schmajuk G, Margaretten M, Barton J, Criswell LA, Yelin EH
- Issue date: 2013 Jan
- What predicts obesity in patients with rheumatoid arthritis? An investigation of the interactions between lifestyle and inflammation.
- Authors: Stavropoulos-Kalinoglou A, Metsios GS, Smith JP, Panoulas VF, Douglas KM, Jamurtas AZ, Koutedakis Y, Kitas GD
- Issue date: 2010 Feb
- Low body mass index but high percent body fat in Taiwanese subjects: implications of obesity cutoffs.
- Authors: Chang CJ, Wu CH, Chang CS, Yao WJ, Yang YC, Wu JS, Lu FH
- Issue date: 2003 Feb