Smoking significantly increases basal metabolic rate in patients with rheumatoid arthritis.
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
AuthorsMetsios, Giorgos S.
Nevill, Alan M.
Douglas, Karen M. J.
Kitas, George D.
MetadataShow full item record
AbstractOBJECTIVE: Basal metabolic rate (BMR) is the most important indicator of human metabolism and its abnormalities have been linked to undesirable health outcomes. Cigarette smoking associates with increased BMR in healthy individuals; it is also related with worse disease outcomes in patients with rheumatoid arthritis (RA), in whom BMR is high, due to hypercatabolism caused by systemic inflammation. We aimed to investigate whether smokers with RA demonstrated higher BMR levels than their non-smoking counterparts. METHODS: Fifty three patients with RA (36 female, 20 current smokers) were assessed for: BMR (indirect calorimetry), anthropometrical data, fat-free mass (bioelectrical impedance), physical function (health assessment questionnaire-HAQ) and disease activity (disease activity score DAS28 and C reactive protein). RESULTS: RA smokers and non-smokers were not significantly different for age, height, weight, body mass index and fat-free mass. Compared to non-smokers, smokers with RA demonstrated significantly higher BMR (1513.9+/-263.3 vs. 1718.1+/-209.2 kcal/day; p=0.000) and worse HAQ (1.0+/-0.8 vs. 1.7+/-0.8; p=0.01). The BMR difference was significantly predicted by the interaction smoking/gender (p=0.04). BMR was incrementally higher in light, moderate and heavy smokers (p=0.018), and correlated with the daily number of cigarettes smoked (r=0.68, p=0.04). CONCLUSION: Current cigarette smoking further increases BMR in patients with RA and has a negative impact on patients' self-reported functional status. Education regarding smoking cessation is needed for the RA population.
CitationAnnals of the Rheumatic Diseases, 67: 70–73
JournalAnnals of the Rheumatic Diseases
CollectionsSport, Exercise and Health Research Group
- Blockade of tumour necrosis factor-alpha in rheumatoid arthritis: effects on components of rheumatoid cachexia.
- Authors: Metsios GS, Stavropoulos-Kalinoglou A, Douglas KM, Koutedakis Y, Nevill AM, Panoulas VF, Kita M, Kitas GD
- Issue date: 2007 Dec
- Smoking at onset of rheumatoid arthritis (RA) and its effect on disease activity and functional status: experiences from BARFOT, a long-term observational study on early RA.
- Authors: Söderlin MK, Petersson IF, Bergman S, Svensson B, BARFOT study group.
- Issue date: 2011
- Quantification of the influence of cigarette smoking on rheumatoid arthritis: results from a population based case-control study, using incident cases.
- Authors: Stolt P, Bengtsson C, Nordmark B, Lindblad S, Lundberg I, Klareskog L, Alfredsson L, EIRA study group.
- Issue date: 2003 Sep
- Association of concomitant fibromyalgia with worse disease activity score in 28 joints, health assessment questionnaire, and short form 36 scores in patients with rheumatoid arthritis.
- Authors: Ranzolin A, Brenol JC, Bredemeier M, Guarienti J, Rizzatti M, Feldman D, Xavier RM
- Issue date: 2009 Jun 15
- Smoking and disease severity in rheumatoid arthritis: association with polymorphism at the glutathione S-transferase M1 locus.
- Authors: Mattey DL, Hutchinson D, Dawes PT, Nixon NB, Clarke S, Fisher J, Brownfield A, Alldersea J, Fryer AA, Strange RC
- Issue date: 2002 Mar