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    Gain of 1q and loss of 22 are the most common changes detected by comparative genomic hybridisation in paediatric ependymoma.

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    Authors
    Ward, Samantha
    Harding, Brian
    Wilkins, Peter
    Harkness, William
    Hayward, Richard
    Darling, John L.
    Thomas, David G.
    Warr, Tracy
    Issue Date
    2001
    
    Metadata
    Show full item record
    Abstract
    Ependymomas are the third most common brain tumour in the paediatric population. Although cytogenetic and molecular analyses have pinpointed deletions of chromosomes 6q, 17, and 22 in a subset of tumours, definitive patterns of genetic aberrations have not been determined. In the present study, we analysed 40 ependymomas from paediatric patients for genomic loss or gain using comparative genomic hybridisation (CGH). Eighteen of the tumours (45%) had no detectable regions of imbalance. In the remaining cases, the most common copy number aberrations were loss of 22 (25% of tumours) and gain of 1q (20%). Three regions of high copy number amplification were noted at 1q24-31 (three cases), 8q21-23 (two cases), and 9p (one case). Although there was no association with the loss or gain of any chromosome arm or with benign versus anaplastic histologic characteristics, the incidence of gain of 7q and 9p and loss of 17 and 22 was significantly higher in recurrent versus primary tumours. This study has identified a number of chromosomal regions that may contain candidate genes involved in the development of different subgroups of ependymoma.
    Citation
    Genes, Chromosomes and Cancer, 32(1): 59-66
    Publisher
    Wiley Interscience
    URI
    http://hdl.handle.net/2436/16712
    DOI
    10.1002/gcc.1167
    PubMed ID
    11477662
    Additional Links
    http://www3.interscience.wiley.com/cgi-bin/abstract/84503984/
    Type
    Journal article
    Language
    en
    Description
    Metadata only
    ISSN
    1045-2257
    ae974a485f413a2113503eed53cd6c53
    10.1002/gcc.1167
    Scopus Count
    Collections
    Research Institute in Healthcare Science

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