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    Identification of extensive genomic loss and gain by comparative genomic hybridisation in malignant astrocytoma in children and young adults.

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    Authors
    Warr, Tracy
    Ward, Samantha
    Burrows, J.
    Harding, Brian
    Wilkins, Peter
    Harkness, William
    Hayward, Richard
    Darling, John L.
    Thomas, David G.
    Issue Date
    2001
    
    Metadata
    Show full item record
    Abstract
    Although astrocytomas are the most common central nervous system tumours in all age groups, there is substantial evidence that tumours arising in young patients (< 25 years of age) do not have the same genetic abnormalities that are characteristic of tumours in older patients. Furthermore, novel, consistent changes have not been identified in astrocytomas in children and young adults. We analysed 13 malignant astrocytomas from young patients using comparative genomic hybridisation. Regions of genomic imbalance were identified in 10 cases. The most common recurrent copy number aberrations were loss of 16p (54% of cases), 17p (38%), 19p (38%), and 22 (38%) and gain on 2q (38%), 12q (38%), 13 (38%), 4q (31%), 5q (31%), and 8q (31%). Seven regions of high copy number amplification were observed at 8q21-22 (three cases), 7q22-23 (two cases), and 1p21-22, 2q22, 12q13-pter, 12q15-21, and 13q11-14 (one case each). This study provides evidence of new characteristic chromosomal imbalances from which potential candidate genes involved in the development of malignant astrocytoma in children and young adults may be identified.
    Citation
    Genes, Chromosomes and Cancer, 31(1): 15-22
    Publisher
    Wiley Interscience
    URI
    http://hdl.handle.net/2436/16694
    DOI
    10.1002/gcc.1113
    PubMed ID
    11284031
    Additional Links
    http://www3.interscience.wiley.com/cgi-bin/abstract/77005859/
    Type
    Journal article
    Language
    en
    Description
    Metadata only
    ISSN
    1045-2257
    ae974a485f413a2113503eed53cd6c53
    10.1002/gcc.1113
    Scopus Count
    Collections
    Research Institute in Healthcare Science

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