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    The influence of small fibre muscle mechanoreceptors on the cardiac vagus in humans.

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    Authors
    Gladwell, V.F.
    Fletcher, Janine
    Patel, N.
    Elvidge, L.J.
    Lloyd, D.
    Chowdhary, Saqib
    Coote, John H.
    Issue Date
    2005
    
    Metadata
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    Abstract
    We have previously shown that activation of muscle receptors by passive stretch (PS) increases heart rate (HR) with little change in blood pressure (BP). We proposed that PS selectively inhibits cardiac vagal activity. We attempted to test this by performing PS during experimental alterations in vagal tone. Large decreases in vagal tone were induced using either glycopyrrolate or mild rhythmic exercise. Milder alterations in vagal tone were achieved by altering carotid baroreceptor input: neck pressure (NP) or neck suction (NS). PS of the triceps surae was tested in 14 healthy human volunteers. BP, ECG and respiration were recorded. PS alone caused a significant decrease (P < 0.05) in R-R interval (962 +/- 76 ms at baseline compared to 846 +/- 151 ms with PS), and showed a reduction in HR variability, which was not significant. The decrease in R-R interval with PS was significantly less (P < 0.05, n = 3) following administration of glycopyrrolate (-8.1 +/- 4.5 ms) compared to PS alone (-54 +/- 11 ms), and also with PS during handgrip (+10 +/- 10 ms) compared with PS alone (-74 +/- 15 ms) (P < 0.05, n = 5). Milder reductions in vagal activity (NP) resulted in a small but insignificant further decrease in R-R interval in response to PS (-107 +/- 17 ms compared to PS alone -96 +/- 13 ms, n = 5). Mild increases in vagal activity (NS) during PS resulted in smaller decreases in R-R interval (-39 +/- 5.5 ms) compared to PS alone (-86 +/- 17 ms) (P < 0.05, n = 8). BP was not significantly changed by stretch in any tests. The results indicate that amongst muscle receptors there is a specific group activated by stretch that selectively inhibit cardiac vagal tone to produce tachycardia.
    Citation
    Journal of Physiology, 567(2): 713-721
    Publisher
    The Physiological Society / Wiley InterScience
    URI
    http://hdl.handle.net/2436/15856
    DOI
    10.1113/jphysiol.2005.089243
    PubMed ID
    15946971
    Additional Links
    https://physoc.onlinelibrary.wiley.com/doi/full/10.1113/jphysiol.2005.089243
    Type
    Journal article
    Language
    en
    Description
    Metadata only
    ISSN
    0022-3751
    ae974a485f413a2113503eed53cd6c53
    10.1113/jphysiol.2005.089243
    Scopus Count
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    Faculty of Education, Health and Wellbeing

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