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    Elucidation of the mechanisms underlying the angiogenic effects of ginsenoside Rg(1) in vivo and in vitro.

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    Authors
    Yue, Patrick Y. K.
    Wong, Daisy Y. L.
    Ha, Wai-Yan
    Fung, M.C.
    Mak, Nai Ki
    Yeung, H.W.
    Leung, Hei Wun
    Chan, Kelvin C.
    Liu, Liang
    Fan, T. P. David
    Wong, Ricky N. S.
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    Issue Date
    2005
    
    Metadata
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    Abstract
    The major active constituents of ginseng are ginsenosides, and Rg(1) is a predominant compound of the total extract. Recent studies have demonstrated that Rg(1) can promote angiogenesis in vivo and in vitro. In this study, we used a DNA microarray technology to elucidate the mechanisms of action of Rg(1). We report that Rg(1) induces the proliferation of HUVECs, monitored using [(3)H]-thymidine incorporation and Trypan blue exclusion assays. Furthermore, Rg(1) (150-600 nM) also showed an enhanced tube forming inducing effect on the HUVEC. Rg(1) was also demonstrated to promote angiogenesis in an in vivo Matrigel plug assay, and increase endothelial sprouting in the ex vivo rat aorta ring assay. Differential gene expression profile of HUVEC following treatment with Rg(1) revealed the expression of genes related to cell adhesion, migration and cytoskeleton, including RhoA, RhoB, IQGAP1, CALM2, Vav2 and LAMA4. Our results suggest that Rg(1) can promote angiogenesis in multiple models, and this effect is partly due to the modulation of genes that are involved in the cytoskeletal dynamics, cell-cell adhesion and migration.
    Citation
    Angiogenesis, 8(3): 205-216
    Publisher
    Springer Verlag
    URI
    http://hdl.handle.net/2436/15833
    DOI
    10.1007/s10456-005-9000-2
    PubMed ID
    16328162
    Additional Links
    http://www.springerlink.com/content/y77908j6248l6362/
    Type
    Journal article
    Language
    en
    Description
    Metadata only
    ISSN
    0969-6970
    ae974a485f413a2113503eed53cd6c53
    10.1007/s10456-005-9000-2
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