The prevalence and clinical significance of autoantibodies to plasminogen activator inhibitor 1 in systemic lupus erythematosus.
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
AuthorsBates, Ruth L.
Payne, Sarah J.
Nelson, Paul N.
Murphy, John J.
MetadataShow full item record
AbstractWe have recently described the novel autoantigen plasminogen activator inhibitor (PAI-1) in systemic lupus erythematosus (SLE). The aim of this study was to determine the prevalence and clinical significance of anti-PAI-1 autoantibodies in patients with SLE. Autoantibodies to recombinant PAI-1 were measured in retrospective sera of 48 lupus patients by immunoassay in order to assess their clinical significance. This showed that 71% of sera from 48 lupus patients had significantly elevated anti-PAI-1 autoantibodies as compared with normal control subjects (P < 0.0001). There was a weak but significant (P < 0.043) correlation with anti-dsDNA autoantibodies. In longitudinal studies, autoantibodies against PAI-1 correlated with clinical parameters measured by the BILAG disease activity index including global clinical score. Our study demonstrates the high frequency of novel autoantibodies to PAI-1 in patients with lupus. The serial clinical correlations with anti-PAI-1 autoantibodies also support the hypothesis that these autoantibodies may play a pathogenic role in lupus.
CitationLupus 2003, 12(8): 617-622
DescriptionMetadata record only
CollectionsMolecular Immunology Research Group
- Autoantibodies against protective molecules--C1q, C-reactive protein, serum amyloid P, mannose-binding lectin, and apolipoprotein A1: prevalence in systemic lupus erythematosus.
- Authors: Shoenfeld Y, Szyper-Kravitz M, Witte T, Doria A, Tsutsumi A, Tatsuya A, Dayer JM, Roux-Lombard P, Fontao L, Kallenberg CG, Bijl M, Matthias T, Fraser A, Zandman-Goddard G, Blank M, Gilburd B, Meroni PL
- Issue date: 2007 Jun
- Investigation of the prevalence and clinical associations of antibodies to human fibronectin in systemic lupus erythematosus.
- Authors: Atta MS, Lim KL, Ala'deen DA, Powell RJ, Todd I
- Issue date: 1995 Feb
- Measurement of autoantibodies using multiplex methodology in patients with systemic lupus erythematosus.
- Authors: Hanly JG, Thompson K, McCurdy G, Fougere L, Theriault C, Wilton K
- Issue date: 2010 Jan 31
- High prevalence of autoantibodies to RNA helicase A in Mexican patients with systemic lupus erythematosus.
- Authors: Vázquez-Del Mercado M, Palafox-Sánchez CA, Muñoz-Valle JF, Orozco-Barocio G, Oregon-Romero E, Navarro-Hernández RE, Salazar-Páramo M, Armendariz-Borunda J, Gámez-Nava JI, Gonzalez-Lopez L, Chan JY, Chan EK, Satoh M
- Issue date: 2010
- Identification of candidate endothelial cell autoantigens in systemic lupus erythematosus using a molecular cloning strategy: a role for ribosomal P protein P0 as an endothelial cell autoantigen.
- Authors: Frampton G, Moriya S, Pearson JD, Isenberg DA, Ward FJ, Smith TA, Panayiotou A, Staines NA, Murphy JJ
- Issue date: 2000 Oct