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    The prevalence and clinical significance of autoantibodies to plasminogen activator inhibitor 1 in systemic lupus erythematosus.

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    Authors
    Bates, Ruth L.
    Payne, Sarah J.
    Drury, S.L.
    Nelson, Paul N.
    Isenberg, D.A.
    Murphy, John J.
    Frampton, Geoffrey
    Issue Date
    2003
    
    Metadata
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    Abstract
    We have recently described the novel autoantigen plasminogen activator inhibitor (PAI-1) in systemic lupus erythematosus (SLE). The aim of this study was to determine the prevalence and clinical significance of anti-PAI-1 autoantibodies in patients with SLE. Autoantibodies to recombinant PAI-1 were measured in retrospective sera of 48 lupus patients by immunoassay in order to assess their clinical significance. This showed that 71% of sera from 48 lupus patients had significantly elevated anti-PAI-1 autoantibodies as compared with normal control subjects (P < 0.0001). There was a weak but significant (P < 0.043) correlation with anti-dsDNA autoantibodies. In longitudinal studies, autoantibodies against PAI-1 correlated with clinical parameters measured by the BILAG disease activity index including global clinical score. Our study demonstrates the high frequency of novel autoantibodies to PAI-1 in patients with lupus. The serial clinical correlations with anti-PAI-1 autoantibodies also support the hypothesis that these autoantibodies may play a pathogenic role in lupus.
    Citation
    Lupus 2003, 12(8): 617-622
    Publisher
    SAGE Publications
    URI
    http://hdl.handle.net/2436/14650
    DOI
    10.1191/0961203303lu436oa
    PubMed ID
    12945721
    Additional Links
    http://direct.bl.uk/bld/PlaceOrder.do?UIN=136076849&ETOC=RN&from=searchenginehttp://lup.sagepub.com/cgi/content/abstract/12/8/617
    Type
    Journal article
    Language
    en
    Description
    Metadata record only
    ISSN
    0961-2033
    ae974a485f413a2113503eed53cd6c53
    10.1191/0961203303lu436oa
    Scopus Count
    Collections
    Research Institute in Healthcare Science

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