• Admin Login
    View Item 
    •   Home
    • Faculty of Education, Health and Wellbeing
    • Faculty of Education, Health and Wellbeing
    • View Item
    •   Home
    • Faculty of Education, Health and Wellbeing
    • Faculty of Education, Health and Wellbeing
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of WIRECommunitiesTitleAuthorsIssue DateSubmit DateSubjectsTypesJournalDepartmentPublisherThis CollectionTitleAuthorsIssue DateSubmit DateSubjectsTypesJournalDepartmentPublisher

    Administrators

    Admin Login

    Local Links

    AboutThe University LibraryOpen Access Publications PolicyDeposit LicenceCOREWIRE Copyright and Reuse Information

    Statistics

    Display statistics

    Liver fat, visceral adiposity, and sleep disturbances contribute to the development of insulin resistance and glucose intolerance in nondiabetic dialysis patients.

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Authors
    Sakkas, Giorgos K
    Karatzaferi, Christina
    Zintzaras, Elias
    Giannaki, Christoforos D
    Liakopoulos, Vassilios
    Lavdas, Eleftherios
    Damani, Eleni
    Liakos, Nikos
    Fezoulidis, Ioannis
    Koutedakis, Yiannis
    Stefanidis, Ioannis
    Show allShow less
    Issue Date
    2008-12
    
    Metadata
    Show full item record
    Abstract
    Hemodialysis patients exhibit insulin resistance (IR) in target organs such as liver, muscles, and adipose tissue. The aim of this study was to identify contributors to IR and to develop a model for predicting glucose intolerance in nondiabetic hemodialysis patients. After a 2-h, 75-g oral glucose tolerance test (OGTT), 34 hemodialysis patients were divided into groups with normal (NGT) and impaired glucose tolerance (IGT). Indices of insulin sensitivity were derived from OGTT data. Measurements included liver and muscle fat infiltration and central adiposity by computed tomography scans, body composition by dual energy X-ray absorptiometer, sleep quality by full polysomnography, and functional capacity and quality of life (QoL) by a battery of exercise tests and questionnaires. Cut-off points, as well as sensitivity and specificity calculations were based on IR (insulin sensitivity index by Matsuda) using a receiver operator characteristics (ROC) curve analysis. Fifteen patients were assigned to the IGT, and 19 subjects to the NGT group. Intrahepatic fat content and visceral adiposity were significantly higher in the IGT group. IR indices strongly correlated with sleep disturbances, visceral adiposity, functional capacity, and QoL. Visceral adiposity, O2 desaturation during sleep, intrahepatic fat content, and QoL score fitted into the model for predicting glucose intolerance. A ROC curve analysis identified an intrahepatic fat content of > 3.97% (sensitivity, 100; specificity, 35.7) as the best cutoff point for predicting IR. Visceral and intrahepatic fat content, as well as QoL and sleep seemed to be involved at some point in the development of glucose intolerance in hemodialysis patients. Means of reducing fat depots in the liver and splachnic area might prove promising in combating IR and cardiovascular risk in hemodialysis patients.
    Citation
    American journal of physiology. Regulatory, integrative and comparative physiology, 295 (6): R1721-9
    Publisher
    American Physiological Society
    Journal
    American journal of physiology. Regulatory, integrative and comparative physiology
    URI
    http://hdl.handle.net/2436/111404
    DOI
    10.1152/ajpregu.00935.2007
    PubMed ID
    18832089
    Type
    Journal article
    Language
    en
    ISSN
    0363-6119
    ae974a485f413a2113503eed53cd6c53
    10.1152/ajpregu.00935.2007
    Scopus Count
    Collections
    Faculty of Education, Health and Wellbeing

    entitlement

    Related articles

    • Trunk muscle quality assessed by computed tomography: Association with adiposity indices and glucose tolerance in men.
    • Authors: Maltais A, Alméras N, Lemieux I, Tremblay A, Bergeron J, Poirier P, Després JP
    • Issue date: 2018 Aug
    • Visceral, subcutaneous abdominal adiposity and liver fat content distribution in normal glucose tolerance, impaired fasting glucose and/or impaired glucose tolerance.
    • Authors: Borel AL, Nazare JA, Smith J, Aschner P, Barter P, Van Gaal L, Eng Tan C, Wittchen HU, Matsuzawa Y, Kadowaki T, Ross R, Brulle-Wohlhueter C, Alméras N, Haffner SM, Balkau B, Després JP
    • Issue date: 2015 Mar
    • Study of genetic prediabetic south Indian subjects. Importance of hyperinsulinemia and beta-cell dysfunction.
    • Authors: Snehalatha C, Ramachandran A, Satyavani K, Latha E, Viswanathan V
    • Issue date: 1998 Jan
    • Adipose Tissue Insulin Resistance in Youth on the Spectrum From Normal Weight to Obese and From Normal Glucose Tolerance to Impaired Glucose Tolerance to Type 2 Diabetes.
    • Authors: Kim JY, Bacha F, Tfayli H, Michaliszyn SF, Yousuf S, Arslanian S
    • Issue date: 2019 Feb
    • Glucose tolerance is affected by visceral adiposity and sex, but not birth weight, in Yucatan miniature pigs.
    • Authors: McKnight LL, Myrie SB, Mackay DS, Brunton JA, Bertolo RF
    • Issue date: 2012 Feb
    DSpace software (copyright © 2002 - 2023)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.