Rheumatoid Arthritis is Associated with IgG Antibodies to Human Endogenous Retrovirus Gag Matrix: A Potential Pathogenic Mechanism of Disease?
Nelson, Paul N Roden, Denise Nevill, Alan M. Freimanis, Graham L Trela, Malgorzata Ejtehadi, Hora Davari Bowman, Simon Axford, John Veitch, Andy M Tugnet, Nicola
Nelson, Paul N
Roden, Denise
Nevill, Alan M.
Freimanis, Graham L
Trela, Malgorzata
Ejtehadi, Hora Davari
Bowman, Simon
Axford, John
Veitch, Andy M
Tugnet, Nicola
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2014-10
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Abstract
Human endogenous retrovirus (HERV)-K10 has been implicated in the etiology and pathogenesis of rheumatoid arthritis (RA). A secondary immune response to this virus might suggest an antigen-driven response in patients. The Gag region of HERV-K10 could provide a key epitope important for immunological reactivity. We investigated the presence of IgG antibodies to this region and assessed its significance in RA.
Citation
Rheumatoid Arthritis is Associated with IgG Antibodies to Human Endogenous Retrovirus Gag Matrix: A Potential Pathogenic Mechanism of Disease? 2014, 41 (10):1952-60 J. Rheumatol.
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Research Unit
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25225282
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Journal article
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en
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0315-162X
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Archived with thanks to The Journal of rheumatology