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Antioxidants and AP-1 activation: a brief overview.
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|Title: ||Antioxidants and AP-1 activation: a brief overview.|
|Citation: ||Immunobiology, 198(1-3): 273-278|
|Publisher: ||Elsevier BV|
|Issue Date: ||1997 |
|PubMed ID: ||9442398|
|Additional Links: ||http://cat.inist.fr/?aModele=afficheN&cpsidt=10321900|
|Submitted date: ||2007-01-24|
|Abstract: ||Activity of the transcription factor AP-1 is controlled by different MAPK cascades that regulate the different AP-1 components at the transcriptional and posttranscriptional level. Recently, AP-1 has been shown to behave as a redox-sensitive transcription factor that can be induced under both pro-oxidative and antioxidative conditions. In this overview we summarize the signaling pathways that converge on the activation of AP-1 and the components of these pathways that have been shown to be targets of antioxidants. The activation of AP-1 by antioxidants may account for the expression of a number of genes that mediate important functions under physiological conditions.|
|Description: ||Metadata only|
|Keywords: ||Transcription factor|
|Appears in Collections: ||Molecular Pharmacology Research Group|
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