Wolverhampton Intellectual Repository and E-Theses >
Research Institutes >
Research Institute in Healthcare Science >
Molecular Pharmacology Research Group >
Antioxidants and AP-1 activation: a brief overview.
this identifier to cite or link
to this item:
|Title: ||Antioxidants and AP-1 activation: a brief overview.|
|Citation: ||Immunobiology, 198(1-3): 273-278|
|Publisher: ||Elsevier BV|
|Issue Date: ||1997 |
|PubMed ID: ||9442398|
|Additional Links: ||http://cat.inist.fr/?aModele=afficheN&cpsidt=10321900|
|Submitted date: ||2007-01-24|
|Abstract: ||Activity of the transcription factor AP-1 is controlled by different MAPK cascades that regulate the different AP-1 components at the transcriptional and posttranscriptional level. Recently, AP-1 has been shown to behave as a redox-sensitive transcription factor that can be induced under both pro-oxidative and antioxidative conditions. In this overview we summarize the signaling pathways that converge on the activation of AP-1 and the components of these pathways that have been shown to be targets of antioxidants. The activation of AP-1 by antioxidants may account for the expression of a number of genes that mediate important functions under physiological conditions.|
|Description: ||Metadata only|
|Keywords: ||Transcription factor|
|Appears in Collections: ||Molecular Pharmacology Research Group|
|Files in This Item:|
There are no files associated with this item.
|Related articles on PubMed|
Thioredoxin reductase regulates AP-1 activity as well as thioredoxin nuclear localization via active cysteines in response to ionizing radiation.
Karimpour S, Lou J, Lin LL, Rene LM, Lagunas L, Ma X, Karra S, Bradbury CM, Markovina S, Goswami PC, Spitz DR, Hirota K, Kalvakolanu DV, Yodoi J, Gius D
2002 Sep 12
|See all 84 articles|
All Items in WIRE are protected by copyright, with all rights reserved, unless otherwise indicated.