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Wolverhampton Intellectual Repository and E-Theses > Research Institutes > Research Institute in Healthcare Science > Molecular Pharmacology Research Group > Antioxidants and AP-1 activation: a brief overview.

Please use this identifier to cite or link to this item: http://hdl.handle.net/2436/7746
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Title: Antioxidants and AP-1 activation: a brief overview.
Authors: Gómez del Arco, Pablo
Martínez-Martínez, Sara
Calvo, Victor
Armesilla, Angel Luis
Redondo, Juan Miguel
Citation: Immunobiology, 198(1-3): 273-278
Publisher: Elsevier BV
Issue Date: 1997
URI: http://hdl.handle.net/2436/7746
PubMed ID: 9442398
Additional Links: http://cat.inist.fr/?aModele=afficheN&cpsidt=10321900
http://direct.bl.uk/bld/PlaceOrder.do?UIN=037406284&ETOC=RN&from=searchengine
Abstract: Activity of the transcription factor AP-1 is controlled by different MAPK cascades that regulate the different AP-1 components at the transcriptional and posttranscriptional level. Recently, AP-1 has been shown to behave as a redox-sensitive transcription factor that can be induced under both pro-oxidative and antioxidative conditions. In this overview we summarize the signaling pathways that converge on the activation of AP-1 and the components of these pathways that have been shown to be targets of antioxidants. The activation of AP-1 by antioxidants may account for the expression of a number of genes that mediate important functions under physiological conditions.
Type: Article
Language: en
Description: Metadata only
Keywords: Transcription factor
AP-1
Antioxidants
ISSN: 0171-2985
Appears in Collections: Molecular Pharmacology Research Group

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